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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON,Washington, D.C. 20549

                                  --------------------



                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a)14(A) of the Securities
                              Exchange Act of 1934

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Filed by the Registrant |X|

Filed by a Party other than the Registrant  |_|

Check the appropriate box:

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                  |X||_|      Preliminary Proxy Statementproxy statement
|_|      Confidential, forFor Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
|_||X|      Definitive Proxy Statementproxy statement
|_|      Definitive Additional Materials
|_|      Soliciting Material Pursuant toUnder ss. 240.14a-11(c) or240.14a-12

                         QUANTRX BIOMEDICAL CORPORATION
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                            A-FEM MEDICAL CORPORATION
                ------------------------------------------------
                (Name of Registrant as Specified in Itsits Charter)
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    (Name- --------------------------------------------------------------------------------
    (Names of Person(s) Filing Proxy Statement, if other thanOther Than the Registrant)


- --------------------------------------------------------------------------------Payment of Filing Fee (Check the appropriate box):
|X| No fee required

|_|      Fee computed on table below per Exchange Act Rules 14a-6(i)(4)
         and 0-11.

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         (2) Aggregate number of securities to which transaction applies:

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             computed pursuant to Exchange Act Rule 0-11 (Set forth the
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|_| Fee paid previously with preliminary materials:

|_| Check box if any part of the fee is offset as provided by Exchange Act Rule
0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number, or
the Form or Schedule and the date of its filing.

         (1) Amount previously paid:

         (2) Form, Schedule or Registration Statement No.:

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         (4) Date Filed:


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                         A-FEM MEDICALQUANTRX BIOMEDICAL CORPORATION
                        10180 S.W. Nimbus Avenue,100 South Main Street, Suite J-5
                             Portland, Oregon 97223

                                February 9, 2001300
                         Doylestown, Pennsylvania 18901


May 31, 2007

Dear Stockholder:

         You areStockholders:

         On behalf of the board of directors and management of QuantRx
Biomedical Corporation (the "Company"), I cordially invitedinvite you to attend a Specialour
annual meeting of stockholders to be held on Thursday, June 28, 2007 at 10:00
a.m. local time, at The Racquet Club of Philadelphia, 215 South 16th Street,
Philadelphia, PA 19102.

         The matters to be acted upon at the annual meeting are fully described
in the enclosed Notice of the Annual Meeting of Stockholders (the "Special Meeting")and accompanying
proxy statement. The Company's board of A-Fem Medical Corporation (the "Company").

                  Place:            A-Fem Medical Corporation
                                    10180 SW Nimbus Avenue, Suite J-5
                                    Portland, Oregon

                  Date:             Thursday, March 8, 2001

                  Time:             9:30 a.m. local time

         Thedirectors recommends a vote "FOR" the
proposals listed as items 1, 2 and 3 in the Notice ofand described in the Special Meeting and Proxy Statement accompany this
letter. The Proxy Statement describes the businessenclosed
proxy statement.

         Your vote is important to be transacted at the
meeting and provides other information concerning the Company.

         The principal business to be transacted at the Special Meeting will be
(i) election of directors; (ii) amendment of the Articles of Incorporation to
increase the authorized number of shares of the Company's common stock ("Common
Stock") and preferred stock ("Preferred Stock"); (iii) amendment of the
Company's Amended and Restated 1994 Incentive and Non-Qualified Stock Option
Plan (the "1994 Plan") to increase the number of shares of Common Stock reserved
for issuance under the 1994 Plan; and (iv) ratification of the appointment of
Arthur Andersen LLP as the Company's independent public accountants for the
fiscal year ending December 31, 2001. The Board of Directors recommends that
stockholders vote for election of the nominated directors, amendment of the
Articles of Incorporation to increase authorized number of shares of Common
Stock and Preferred Stock, amendment of the 1994 Plan and ratification of Arthur
Andersen LLP as the Company's independent public accountants.

         We know that many of our stockholders will be unable to attend the
Special Meeting. Proxies are therefore solicited so that each stockholder has an
opportunity to vote on all matters that are scheduled to come before the
meeting.us. Whether or not you plan to attend in
person, it is important that your shares be represented and voted at the Special Meeting, we hope that you
will have your stock represented by marking, signing, datingannual
meeting. Therefore, after reading the enclosed proxy statement, please promptly
complete, sign, date, and returningreturn your proxy card in the enclosed envelope as soon as possible.envelope. Your
stock will be voted in accordance with the instructions you have given in your
proxy card. You may, of course, attend the Special Meetingannual meeting and vote in person
even if you have previously returned your proxy card.

         We look forward to greeting you at the meeting.

                                Sincerely,



                                Steven T. Frankel
                                PresidentWalter Witoshkin
                                Chairman and Chief Executive Officer


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                                    IMPORTANT

A proxy card is enclosed herewith. All stockholders are urged to complete and
mail the proxy card promptly. The enclosed envelope for return of the proxy card
requires no postage. Any stockholder attending the Special Meeting may
personally vote on all matters that are considered, in which event the signed
proxy will be revoked.

                    IT IS IMPORTANT THAT YOUR STOCK BE VOTED.

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                         A-FEM MEDICALQUANTRX BIOMEDICAL CORPORATION

                    NOTICE OF SPECIALANNUAL MEETING OF STOCKHOLDERS

                           TO BE HELD MARCH 8, 2001To be Held on June 28, 2007

To the Stockholders of QuantRx Biomedical Corporation:

         NOTICE IS HEREBY GIVEN that the Special Meetingannual meeting of Stockholdersstockholders (the
"Special"Annual Meeting") of A-Fem MedicalQuantRx Biomedical Corporation, a Nevada corporation (the
"Company"), will be held on Thursday, March 8, 2001,June 28, 2007, at 9:3010:00 a.m. local time,
at the Company's offices at 10180 SW Nimbus Avenue, Suite J-5, Portland, Oregon,The Racquet Club of Philadelphia, 215 South 16th Street, Philadelphia, PA
19102, for the following purposes:

         1.  To(1) to elect seven directorstwo Class 1 Directors, to hold office until the Company's Board2009
         annual meeting of Directors.

         2. To amend the Company's Articles of Incorporation to increase the
authorized number of shares of the Company's Common Stockstockholders or until their respective successors
         have been duly elected, and Preferred Stock.

         3. To amend the Company's Amended and Restated 1994 Incentive and
Non-Qualified Plan (the "1994 Plan") to increase the number of shares of the
Company's Common Stock reserved for issuance under the 1994 Plan.

         4. To ratify the appointment of Arthur Andersen LLPone Class 2
         Director who was appointed by the Company's board of directors in
         September 2006 to fill a vacancy;

         (2) to approve the Company's 2007 Incentive and Non-Qualified Stock
         Option Plan;

         (3) to ratify the appointment of Williams & Webster, P.S. as the
         Company's independent public accountants for the fiscal year ending
         December 31, 2001.

         Only2007; and

         (4) to transact such other business as may properly come before the
         Annual Meeting or at any adjournments or postponements thereof.

         QuantRx's board of directors has fixed May 9, 2007 as the record date
for determining stockholders of record at the close of business on January 30,
2001, will be entitled to notice of and to vote at the SpecialAnnual
Meeting or any adjournment or postponement thereof.

         TheA proxy statement explaining the matters to be acted upon at the Annual
Meeting is enclosed herewith. This proxy solicitation material is being mailed
to stockholders on or about May 31, 2007, and includes a copy of the Company's
Proxy Statement is submitted herewith. Financial and
other information concerning2006 Annual Report to Stockholders.

         QuantRx's board of directors unanimously recommends you vote "FOR" the
Company is containedproposals presented to you in the enclosed Annual
Report.

         ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTENDthis proxy statement.

         IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED AT THE SPECIALANNUAL MEETING.
WHETHER OR NOT YOU PLAN TO ATTEND THE SPECIAL MEETING,
PLEASE COMPLETE, SIGN AND DATE THE ENCLOSED PROXY CARD REGARDLESS OF WHETHER YOU
PLAN TO ATTEND THE MEETING, AND RETURN IT AS PROMPTLY AS POSSIBLE IN THE
ENCLOSED POSTAGE PREPAID ENVELOPE IN ORDER THAT THE PRESENCE OF A QUORUM MAY BE
ASSURED. THE GIVING OF SUCH PROXY DOES NOT AFFECT YOUR RIGHT TO REVOKE IT LATER
OR VOTE YOUR SHARES IN PERSON IN THE EVENT THAT YOU SHOULD ATTEND THE SPECIAL
MEETING.

By Order of the Board of Directors,

Steven T. Frankel, PresidentWalter Witoshkin, Chairman and Chief Executive Officer
Portland, Oregon
February 9, 2001Doylestown, Pennsylvania

May 31, 2007





                         A-FEM MEDICALQUANTRX BIOMEDICAL CORPORATION
                        10180 S.W. Nimbus,100 South Main Street, Suite J-5
                             Portland, Oregon 97223300
                         Doylestown, Pennsylvania 18901
                                 PROXY STATEMENT


             FOR SPECIAL MEETING OF STOCKHOLDERS
                      TO BE HELD ON THURSDAY, MARCH 8, 2001GENERAL INFORMATION CONCERNING SOLICITATION AND VOTING

General

This Proxy Statementproxy statement is furnished by the Board of Directors of A-Fem
Medical Corporation, a Nevada corporation (the "Company"), to the holdersstockholders of common stock, par value $.01 per share,QuantRx Biomedical
Corporation, of the Company (the "Common Stock") and
the holdersrecord as of the Series A Convertible Preferred Stock, $.01 par value (the
"Series A Stock")May 9, 2007, in connection with the solicitation of
proxies by the Board of Directors (the "Board") of the Company for use at the Company's
SpecialAnnual Meeting of Stockholders in lieu of an
annual meeting (the "Special"Annual Meeting"), to be held at 9:30 a.m. local time, on Thursday,
March 8, 2001,June 28, 2007, at 10:00 a.m. EDT, at The Racquet Club of Philadelphia, 215 South
16th Street, Philadelphia, PA 19102.

The approximate date for mailing of the Company's offices at 10180 SW Nimbus Avenue,
Suite J-5, Portland, Oregon.

         This Proxy StatementNotice of Annual Meeting of
Stockholders, this proxy statement and the enclosed form of proxy were mailed to
stockholders on or about February 9, 2001.is May 31, 2007.

Record Date and Outstanding Shares

Only holders of record of the Company's Common Stock and Series A Stock
atcommon stock on May 9, 2007, or the
close of business on January 30, 2001,record date, are entitled to notice of and to vote at the SpecialAnnual Meeting. OnAs of
that date, 9,596,558there were 40,910,580 shares of Common Stockcommon stock outstanding and 7,492,135 shares of Series A Stock were outstanding (together, holders
are entitled to one vote per share ("the "OutstandingOutstanding Shares").

Solicitation of Proxies

The cost of preparing, printing and mailing this Proxy Statementproxy statement and the proxy
solicited hereby has been or will be borne by the Company. In addition to the use of the mails,this
mailing, proxies may be solicited by directors, officers and other employees of
the Company, without additional remuneration, in person or by telephone or
facsimile transmission. The Company will also request brokerage firms, bank
nominees, custodians, and fiduciaries to forward proxy materials to the
beneficial owners of the Common Stockstockholders as of the record date and will provide reimbursement for the cost
of forwarding the proxy materials in accordance with customary practice. Your
cooperation in promptly completing, signing, dating and returning the enclosed
proxy card will help avoid additional expense.

Quorum and Voting

Each Outstanding Share entitles the holder thereof to one vote upon each matter
to be presented at the SpecialAnnual Meeting. Holders of the Common Stock
and Series A StockStockholders are not entitled to
cumulative voting rights in the election of directors. A quorum, consisting of
one-third of the Outstanding Shares, must be present in person or by proxy for
the transaction of business.

If a quorum is present:

 (i)    a nominee for election to the Board of Directors will beare elected (or ratified) by a plurality of the affirmative
        votes cast by those shares present in person, or represented by proxy,
        and entitled to vote at the Special Meeting by holdersAnnual Meeting. This means the nominees for
        directors (and the appointee) receiving the highest number of
        affirmative votes will be elected (or ratified). Abstentions and broker
        non-votes will not affect the election (or ratification) of a candidate
        who receives a plurality of votes.

 (ii)   Adoption of the Outstanding Shares;

                  (ii)2007 Incentive and Non-Qualified Stock Option Plan
        requires the amendment of the Articles of Incorporation, as
previously amended and restated (the "Articles"), to increase the authorized
number of shares of the Common Stock and the Company's preferred stock (the
"Preferred Stock") will be approved if it receives the affirmative vote of a
majority of the Outstanding Shares and the affirmative voteapproval of a majority of the outstanding Series A Stock;



                                      -1-


                  (iii) the amendment of the Company's Amended and Restated 1994
Incentive and Non-Qualified Stock Option Plan (the "1994 Plan") to increase the
number of shares of Common Stock reserved for issuance under the 1994 Plan will
be approved if it receives the affirmative vote of a majority of the Outstanding
Sharesstock
        represented in person or represented by proxy at the Special MeetingAnnual Meeting.
        Abstentions and broker non-votes will not be counted as having been
        voted on the affirmative voteproposal and will have the effect of a majority
ofvoting against the
        outstanding Series A Stock; and

                  (iv) theproposal.

 (iii)  The appointment of Arthur Andersen, LLP,Williams & Webster, P.S., will be ratified if thesuch
        proposal receives the affirmative vote of a majority of the Outstanding
        Shares represented at the SpecialAnnual Meeting. Abstentions and otherbroker


                                       1



        non-votes arewill not be counted as having been voted on the proposal and
        will have the effect of voting against the proposal.

Abstentions and broker non-votes will be included in the determination of the
number of shares present at the Annual Meeting and for purposesthe purpose of
determining whether a quorum exists at the Special Meeting, but have no effect on the determination
ofis present, and each will be tabulated separately.
In determining whether a plurality exists with respect toproposal has been approved, in most cases an abstention
or a given nominee. An abstentionbroker or other non-vote haswill have the same effect ofas a vote against the
proposal. In the election of directors, a proposal. Proxiesbroker non-vote has no effect if a
quorum is present and ballotsdirectors are elected by a plurality.

Each proxy returned to the Company will be receivedvoted in accordance with the
instructions indicated thereon. If no instructions are indicated, the shares
will be voted "FOR" the (i) election of the nominees and tabulatedthe ratification of the
appointee named in this proxy statement as directors, (ii) adoption of the 2007
Incentive and Non-Qualified Stock Option Plan, and (iii) ratification of the
appointment of Williams & Webster, P.S. as independent public accountants for
the fiscal year ending December 31, 2007.

Stockholders holding shares in "street name" with a broker/dealer, financial
institution or other holder of record should review the information provided to
them by Computershare Investor Services, the Company's
transfer agent.holder of record. This information will describe the procedures to
be followed in instructing the holder of record how to vote the "street name"
shares and how to revoke previously given instructions.

Revocability of Proxies

Any proxy delivered pursuant to this solicitation is revocable at the option of
the person giving it at any time before it is exercised. A proxy may be revoked
prior to its exercise by delivering to the Company's Secretary a written notice
of revocation or a duly executed proxy card bearing a later date, or by
attending the SpecialAnnual Meeting and voting in person. Attendance at the SpecialAnnual
Meeting will not in and of itself constitute a revocation of a proxy.


                                       Each proxy returned2



                              CORPORATE GOVERNANCE

The Board of Directors

The Company's board of directors is currently comprised of five directors. The
five directors are divided into two classes comprised of three Class 1 Directors
(William Fleming, Shalom Hirschman, and Evan Levine) and two Class 2 Directors
(Walter Witoshkin and Arthur Hull Hayes, Jr.). Pursuant to the Company's bylaws,
the members of each class serve for a staggered two-year term and, at each
annual meeting of stockholders, a class of directors is elected for a two-year
term to succeed the directors of the same class whose terms are expiring. The
current terms of the Class 1 Directors and Class 2 Directors are set to expire
at the annual meeting of stockholders held following the end of calendar years
2006 and 2007, respectively.

During the fiscal year ended December 31, 2006, the Board held eight meetings
and took action by unanimous written consent six times. During this period,
Walter Witoshkin and William Fleming attended all eight meetings, Shalom
Hirschman attended seven meetings, and Evan Levine attended two meetings. Arthur
Hull Hayes, Jr. attended both meetings held during the period he served on the
Board.

There are no family relationships among the Company's directors, executive
officers or persons nominated or chosen to become directors or executive
officers of the Company.

Board Committees

The Board has two standing committees: an audit committee (the "Audit
Committee") and a compensation committee (the "Compensation Committee").

Audit Committee

The members of the Audit Committee are Shalom Hirschman and William Fleming,
with Mr. Fleming chairing such committee. The Company does not yet have an
"audit committee financial expert," as defined by SEC rules adopted pursuant to
the Sarbanes-Oxley Act of 2002, as a result of its inability to recruit a
qualified candidate with the requisite experience and financial literacy.

The Board recently adopted a written charter for the Audit Committee. As
described in the Audit Committee Charter, the purpose of the Audit Committee
includes, but is not limited to: (1) overseeing the accounting and financial
reporting processes of the Company and audits of the financial statements of the
Company; and (2) providing assistance to the Board with respect to its oversight
of (i) the integrity of the Company's financial statements, (ii) the Company's
compliance with legal and regulatory requirements, (iii) the independent
auditor's qualifications and independence, and (iv) the performance of the
Company's internal audit function, if any, and independent auditor.

The Audit Committee's duties, which are specified in the Audit Committee
Charter, include but are not limited to:

     o   discussing with management and the independent auditor the Company's
         earnings press releases (paying particular attention to the use of any
         "pro forma" or "adjusted" non-GAAP information), as well as financial
         information and earnings guidance provided to analysts and rating
         agencies,

     o   appointing, retaining, compensating, evaluating and terminating any
         accounting firm engaged by the Company for the purpose of preparing or
         issuing an audit report or performing other audit, review or attest
         services for the Company and, in its sole authority, approving all
         audit engagement fees and terms as well as all non-audit engagements
         with the accounting firm,

     o   requiring that the independent auditor, in conjunction with the Chief
         Financial Officer, be responsible for seeking pre-approval for
         providing services to the Company and that any request for
         pre-approval must inform the Audit Committee about each service to be
         provided and must provide detail as to the particular service being
         provided, and


                                       3



     o   informing each accounting firm engaged for the purpose of preparing or
         issuing an audit report or to perform audit, review, or attest
         services for the Company that such firm will be votedreport directly to the
         Audit Committee.

A copy of the Audit Committee Charter is attached hereto as Exhibit A.

Compensation Committee

The members of the Compensation Committee are Arthur Hull Hayes, Jr. and Shalom
Hirschman. The Board recently adopted a written charter for the Compensation
Committee. As described in accordancethe Compensation Committee Charter, the purpose of
the Compensation Committee includes, but is not limited to, recommending to the
Board for determination the compensation for the Chief Executive Officer and all
other officers.

The compensation committee has numerous duties and responsibilities, including
but not limited to:

     o   establishing and reviewing the overall compensation philosophy of the
         Company,

     o   establishing and periodically reviewing policies in the area of senior
         management perquisites, and

     o   considering policies and procedures pertaining to expense accounts of
         senior executives.

A copy of the Compensation Committee Charter is attached hereto as Exhibit B.

Nominating Committee

The Company currently does not have a nominating committee, but intends to
formally constitute a nominating committee and adopt a charter for such
committee. The entire Board currently participates in the recruitment and
selection of director nominees.


                                       4



2006 Audit Committee Report

We, the audit committee, oversee the Company's accounting and financial
reporting processes and assist the Board in its oversight of the qualifications,
independence and performance of the Company's independent auditors. In
fulfilling our oversight responsibilities, we discussed with the instructions indicated thereon. If no instructions are indicated,Company's
independent auditors, Williams & Webster, P.S., the shares
will be voted "FOR" (i) electionoverall scope and plans for
their audit. Upon completion of the nomineesaudit, we discussed with Williams & Webster,
P.S. the matters required to be discussed by Statement on Auditing Standards No.
61.

We also reviewed and discussed the audited financial statements with management.
We discussed certain significant accounting principles, the reasonableness of
significant judgments, and the clarity of disclosures in those financial
statements.

We have also reviewed the written disclosures and the letter from the
independent accountants required by Independence Accounting Standards No. 1 and
discussed with the independent accountants the independent accountants'
independence from management and the Company. We determined that the services
provided by Williams & Webster, P.S. during fiscal year 2006 are compatible with
maintaining such auditor's independence.

In reliance on the reviews and discussions referred to above, we recommended to
the Board (and the Board approved) that the audited financial statements be
included in the Company's Annual Report on Form 10-KSB for the Board of Directors
named in this Proxy Statement; (ii) amendment of the Articles to increase the
authorized number of shares of Common Stock and Preferred Stock; (iii) amendment
of the 1994 Plan; and (iv) ratification of the appointment of Arthur Andersen
LLP as independent public accountants for the fiscal year endingended
December 31, 2001.2006 for filing with the Securities and Exchange Commission.




                                          AUDIT COMMITTEE

                                          William Fleming, Chairman
                                          Shalom Hirschman, Member


                                       5



PROPOSAL NO. 1 - ELECTION OF DIRECTORS

Election of Directors

                  The businessBoard proposes that William Fleming and affairs of the Company are managed under the
direction of its Board of Directors. The Company's Bylaws provide that the Board
of Directors shall consist of not less than five nor more than nine members. The
Company's Bylaws provide for a staggered board. Pursuant to the Bylaws of the
Company, the Board of Directors is divided into two classes, with such classes
toShalom Hirschman be elected as equal in number as the total number of directors constituting the
entire Board permits. After the Special Meeting, the Company's Board of
Directors will consist of seven members, with three members in Class
1 whose
terms will expire in one year or when their respective successors have been
elected and qualified or until their death, resignation or removal fromDirectors to hold office
and four members in Class 2, whose terms will expire in two years or when their
respective successors have been elected and qualified or until their death,
resignation or removal from office. At the expiration of each class's term,
directors are to be elected to serve for a term of two years or until their
respective successors have been elected and qualified or until their death,
resignation or removal from office. A director elected to fill a vacancy on the
Board of Directors will be elected for the unexpired term of his or her
predecessor in office.

         At the Special Meeting, stockholders will elect three Class 1 directors
to serve for one year or(or until successors are
elected and qualifiedqualified) and fourthat the Board's appointment of Arthur Hull Hayes,
Jr. as a Class 2 directorsDirector be ratified. As noted above, each nominee and the
appointee is currently serving as a member of the Board. Each Class 1 and Class
2 Director must be elected (or ratified) by a plurality of the votes properly
cast at the Annual Meeting.

Recommendation

THE BOARD UNANIMOUSLY RECOMMENDS A VOTE FOR THE ELECTION OF THE NOMINEES AND THE
RATIFICATION OF THE APPOINTEE LISTED ABOVE.

             INFORMATION REGARDING DIRECTORS AND EXECUTIVE OFFICERS

The following biographical descriptions set forth certain information with
respect to servethe two nominees for two years or until successors are elected and
qualified. Unless otherwise directed, the persons named in the proxy intend to
cast all proxies in favor of Merry Disney, James E. Reinmuth and RoseAnna Sevcik
to serveelection as Class 1 directors ofDirectors, the Company and William H. Fleming, Steven T.
Frankel, Carol A. Scott, and James R. Wilson to serveappointee for
ratification as a Class 2 directors ofDirector, the Company. In the event that Ms. Disney, Mr. Fleming, Mr. Frankel, Mr.
Reinmuth, Ms. Scott, Ms. Sevcik or Mr. Wilson should become unavailableDirectors who are not nominees for
election, toand the Board of Directors for any reason, the persons named in the
proxy have discretionary authority to vote the proxies for the election of other nominees to be designated to fill each such vacancy by the Board of Directors of
the Company.





                                      -2-


Information about the Nominees and Managementexecutive officers who are not directors.


Directors and Executive Officers Age Position -------------------------------- --- -------- Merry L. Disney 54 DirectorWalter W. Witoshkin 62 Chairman and Chief Executive Officer William H. Fleming, Ph.D. 54 Vice Chairman-Diagnostics,60 Chief Scientific Officer, Secretary, and Director Steven T. Frankel 58Arthur Hull Hayes, Jr., M.D. 73 Director Shalom Hirschman, M.D. 70 Director Evan Levine 41 Director Executive Officers Who are Not Directors ---------------------------------------- Sasha Afanassiev 39 Chief ExecutiveFinancial Officer, PresidentTreasurer, and Director James E. Reinmuth, Ph.D. 60 Chairman and Director Carol A. Scott, Ph.D. 51 Director RoseAnna Sevcik 37 Director James Wilson 51 Treasurer, Director of Business Development and Director Key Employees ------------- Martin Harvey 59 Controller Paul Mueggler, Ph.D. 50 Vice President Clinical and Regulatory Affairsof Finance Cynthia Horton 43 Vice President of Diagnostics
Class 1 Director Nominees; terms expireNominees - Term Expiring in one year. Merry L. Disney has been president and chief executive officer of Disney West operations since 1985. From 1986 to 1988, she was president of Bridaldale Development Corporation and served as a director from 1979 to 1986. Ms. Disney worked as an Academic Instructor of Children with Reading Disabilities from 1982 until 1991 and currently is active in major real estate developments and acquisitions. James E. Reinmuth,2009 WILLIAM H. FLEMING, Ph.D. has served as Chairman of A-Fem since September 1996, and has been a Director of A-Fem since May 1995. From September 1996 to April 1998, Dr. Reinmuth served as Chief ExecutiveScientific Officer of A-Fem. From May 1995 to September 1996, Dr. Reinmuth served as Treasurer of A-Fem. Since July 1994, Dr. Reinmuth has served as the Charles H. Lundquist Distinguished Professor of Business at the University of Oregon. From June 1976 until July 1994, Dr. Reinmuth served as Dean of the College of Business at the University of Oregon. Since 1988, Dr. Reinmuth has also served in several administrative positions within the University of Oregon. RoseAnna Sevcik has served as a Director of A-Fem since May 1995. Ms. Sevcik has been serving as Director of Mortgage Backed Securities for SunAmerica InvestmentsQuantRx since July of 1999. From March 1996 to May 1999, Ms. Sevcik served as vice president/senior portfolio manager of Penn Mutual. From February 1993 to March 1996, Ms. Sevcik was vice president/senior portfolio manager and served as a director on the pension plans board of the Life Insurance Company of the Southwest. From February 1990 to February 1993, Ms. Sevcik was senior portfolio manager/securities analyst at Securities Management and Research, an investment management services company. Class 2 Director Nominees; terms expire in two years. William H. Fleming, Ph.D., has served as Vice Chairman-Diagnostics of A-Fem since August of 1997, and2005, as a Director and Secretary of A-FemQuantRx since February 1994.1994, as Vice Chairman-Diagnostics of QuantRx from August 1997 through July 2005, and as Acting CEO from 2003 until May 2005. From February 1994 through August 1997, Dr. Fleming served as President and Chief Operating Officer of A-Fem. HeQuantRx. In addition, he was president, chief operating officerPresident, Chief Operating Officer and a directorDirector of ProFem from July 1993 until its merger with A-FemQuantRx in June 1994. From April 1992 until July 1993, Dr. Fleming served as an associate with Sovereign Ventures, a healthcare consulting firm; concurrently he served as director of corporate development of Antivirals, Inc., a biotechnology company involved in antisense technology. Dr. Fleming is a director of ERC, a non-profit company. Steven T. Frankelorganization. SHALOM HIRSCHMAN, M.D. has served as a Director of QuantRx since September 2005. Dr. Hirschman was Professor of Medicine, Director of the Division of Infectious Diseases and Vice-Chairman of the Department of Medicine at Mt. Sinai School of Medicine and the Mount Sinai Hospital. He spent nearly three decades at Mt. Sinai until his retirement. He also served as the CEO, President and Chief Scientific Officer of Advanced Viral Research Corp., from which he retired in 2004. Class 2 Director Appointee - Term Expiring in 2008 ARTHUR HULL HAYES, JR., M.D. has served as a Director of QuantRx since September 2006. Dr. Hayes served as Commissioner of the United States Food and Drug Administration from 1981 to 1983. Dr. Hayes founded and was 6 President and Chief Operating Officer of MediScience Associates, Inc., a consulting organization that works with pharmaceutical firms, biomedical companies and foreign governments, from July 1991 to January 2006, and Clinical Professor of Medicine and Pharmacology at the Pennsylvania State University College of Medicine from 1981 to 2004. From 1986 to 1990, Dr. Hayes was President and Chief Executive Officer of E.M. Pharmaceuticals, a North American subsidiary of Germany's E. Merck AG. Other Directors WALTER W. WITOSHKIN is Chairman and Chief Executive Officer of QuantRx Biomedical Corporation. A 40-year veteran of the pharmaceutical, healthcare and biomedical industries, Mr. Witoshkin began serving as a Director of A-Fem since April 1998, and asChief Executive Officer in May, 2005. He has held senior executive positions at leading healthcare product and pharmaceutical companies, most recently SmithKline Beecham, now Glaxo SmithKline, where he was a Vice President of A-Fem since November 1998. From May 1992Business Development and Chief Financial Officer. In 1989, Mr. Witoshkin established Menley & James Laboratories, Inc., after purchasing 32 SmithKline Beecham over-the-counter pharmaceutical and toiletry product brands. Menley & James had its initial public offering in 1992. He earlier held several senior finance positions at American Cyanamid, which became American Home and then Wyeth. Mr. Witoshkin joined QuantRx from Trident Group LLC, global operational consultants to March 1998,the pharmaceutical and related healthcare industries. As a founding partner of Trident Group, Mr. Frankel was presidentWitoshkin specialized in alternative sourcing for manufacturing and chief executive officerthe acquisition of Quidel Corporation, a manufacturer of physicians' office diagnostic test kits. From January 1983 to May 1992,technologies and products. Mr. Frankel was president of various international and domestic divisions of Becton, Dickinson and Company, a diagnostic -3- and medical device manufacturer. From 1979 to 1983, Mr. Frankel was vice president and general manager of the Becton Dickinson Home Health Care unit. Mr. FrankelWitoshkin also serves as a director of HIDA Educational Foundation, Washington, D.C. Carol A. Scott, Ph.D.,Sontra Medical Corporation and a number of privately held companies. Mr. Witoshkin is a Class 2 Director whose term expires in 2008. EVAN LEVINE has served as a Director of A-FemQuantRx since February 1995. Dr. ScottSeptember, 2005, but has informed QuantRx of his intention not to stand for re-election to the Board; therefore, his term will expire at the 2007 Annual Meeting of Stockholders. Mr. Levine is currently Vice Chairman, President and Chief Executive Officer of ADVENTRX Pharmaceuticals, Inc. a publicly traded biotechnology company. Mr. Levine is also the Managing Member of Mark Capital, LLC, a Venture Capital Fund. Mr. Levine has over 18 years of investment banking, venture capital, arbitrage and senior corporate management experience. Mr. Levine is a professor of marketing and the chairman of the marketing faculty at The John E. Anderson Graduate School of Management at the University of California, Los Angeles. Dr. Scott has been on the faculty at UCLA since 1977, and served the schoolClass 1 Director whose term expires in a variety of administrative positions from 1986 through 1994, including as chairman of the faculty and associate dean for academic affairs. She was also a visiting associate professor at the Harvard Business School in 1985, and was on the faculty at Ohio State University for three years prior to joining UCLA in 1977. Dr. Scott is a frequent author and lecturer and2007. Executive Officers Who Are Not Directors SASHA AFANASSIEV, CPA, has served on the Editorial Boardas CFO and Vice President-Finance of the Journal of Consumer ResearchQuantRx since 1980. Dr. Scott also serves on the board of directors of Sizzler International. James R. WilsonSeptember 2005. In addition, Mr. Afanassiev has served as Treasurer of the Company since December 2005. Mr. Afanassiev has seventeen years of diversified public accounting experience. Mr. Afanassiev was the principal and a Directorfounder of A-Fem since September 1996an accounting and as Director of Business Development since July 1997. In addition, since August 1995 Mr. Wilson has been a private financial consultant to firmstax consulting firm, established in both manufacturing and service industries. From August 1992 to August 1995, Mr. Wilson was a sales manager for Advanced Equipment Systems, Inc. From January 1985 to August 1992, Mr. Wilson was treasurer and director of marketing in various divisions of Production Technologies, Inc. Mr. Wilson also serves as a director of Design Pacific/Oregon Dome, Inc. Key Employees Martin Harvey has served as the Company's Controller since June 1998. From 1993 to 1998, Mr. Harvey held several other controller positions with a variety of manufacturing companies. From August 1987 to June 1993, Mr. Harvey was division controller for Spacelabs Medical, Inc., a manufacturer of critical care medical monitors. From January 1980 to August 1987, Mr. Harvey was division controller for the Medical Systems Division of Control Data, Inc. Paul Mueggler, Ph.D.2001. CYNTHIA HORTON has served as Vice President, ClinicalPresident-Diagnostics of QuantRx since July 2005. Ms. Horton was the national sales manager for Applied Biotech, Inc., an Inverness Medical Innovations Company. Prior to that, she directed sales for Drugs of Abuse POC's, Professional POC's for Women's Health and Regulatory Affairsbranded OTC products for private label customers at ABI, and its predecessor Forefront Diagnostics. 7 COMPENSATION OF EXECUTIVE OFFICERS Summary Compensation Table The following Summary Compensation Table sets forth summary information as to compensation received by the Company's Chief Executive Officer and each of the two other most highly compensated persons who were serving as executive officers of the Company since July 2000. Prior to this date, Dr. Mueggler served as Director of Clinical AffairsDecember 31, 2006.
Non-equity Stock Option Incentive Plan All Other Name and Salary Bonus Awards Awards Compensation Compensation Total Principal Position Year ($) ($) ($) ($) ($) ($) ($) - -------------------------------------------------------------------------------------------------------------------------- Walter W. Witoshkin, 2006 240,000 10,000 - 66,454 - - 316,454 Chairman & CEO 2005 112,500 - - 143,836 - - 256,336 Cynthia Horton, 2006 150,000 6,250 - 23,850 - - 180,100 VP of Diagnostics 2005 45,833 - - - - 10,000 55,833 Sasha Afanassiev, 2006 110,167 6,250 - 125,325 - - 241,742 CFO, Treasurer & VP of Finance 2005 19,250 - - - - - 19,250
The amounts in the Option Awards column reflect the dollar amount recognized and expensed for financial statement reporting purposes for the fiscal years ended December 31, 2006 and 2005, in accordance with Statement of Financial Accounting Standards No. 123(R) of awards of stock options and thus do not represent aggregate fair value of grants. The Company since Aprilused the Black-Scholes option price calculation to value the options granted in 2006 and 2005 using the following assumptions: risk-free rate of 1997. From August 19894.93% and 3.78%; volatility of 1.70 and 1.85; actual term and exercise price of options granted. Outstanding Equity Awards At Fiscal Year-end
Option Awards ------------------------------------------------------------------------------------------------ Number of Securities Number of Equity Incentive Plan Underlying Securities Awards: Number of Unexercised Underlying Securities Underlying Options Unexercised Options Unexercised Unearned Option (#) (#) Options Exercise Price Option Expiration Name Exercisable Unexercisable (#) ($) Date - ---------------------------------------------------------------------------------------------------------------------- Walter W. Witoshkin, Chairman & CEO (1) 703,545 - 296,455 $0.50 05/03/2015 Cynthia Horton, VP of Diagnostics (2) - - 100,000 $1.60 04/03/2016 Sasha Afanassiev, CFO, Treasurer & VP 25,000 - - $1.60 04/03/2016 of Finance (3) - 75,000 - $1.15 07/25/2016
(1) Options granted 05/03/2005 vest as follows; 333,000 shares vested on May 3, 2005 and the remaining options will continue to vest with respect to 18,527 shares each monthly anniversary thereafter until fully-vested. Term of the options is ten years. Exercise price exceeded the closing stock price on the date of grant. 8 (2) Options granted 04/03/2006 vest upon meeting certain sales milestones which have not yet been met. Term of the options is ten years. Exercise price is equal to the closing stock price on the date of grant. (3) Options granted 04/03/2006 vested immediately. Options granted 07/25/2006 vested January 1994, Dr. Mueggler served1, 2007. Terms of both options are ten years. Exercise prices are equal to the closing stock price on date of grant. There are no outstanding stock awards as director of clinicalDecember 31, 2006. The Company used the Black-Scholes option price calculation to value the options granted in 2006 and technical operations for OXIS Corporation, a diagnostic company. From April 1984 to August 1989, he served as assistant professor2005 using the following assumptions: risk-free rate of 4.93% and chief, toxicology section3.78%; volatility of 1.70 and 1.85; actual term and exercise price of options granted. Employment Agreements We have entered into an employment contract with our Chief Executive Officer that provides for the Departmentcontinuation of Clinical Pathology ofsalary if terminated for reasons other than cause, as defined in those agreements. At December 31, 2006, the School of Medicinefuture employment contract commitment for such key executive based on stated termination clause was approximately $240,000. All other employees are "at-will" employees and may be terminated at Oregon Health Sciences University. THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE ELECTION OF THE NOMINEES. Board of Directors Meetings and Committees andany time by the Company. Director Compensation of Directors The Board of Directors has established an Audit Committee and Compensation Committee, but no Nominating Committee. The Audit Committee oversees actions with respect to the Company's accounting and financial reporting practices and providesadopted a channel of communication between the Board and the Company'scompensation policy in July 2006. QuantRx compensates independent auditors. The Audit Committee consists of Carol A. Scott, Chair, and RoseAnna Sevcik. The Audit Committee held one meeting in 1999. Both members of the Audit CommitteeBoard of Directors with cash compensation of $5,000 and 6,250 stock options per Board meeting attended in person; up to a maximum of four meetings per year. All options are independent directors as defined by NASD Rule 4200(a)(15). The Audit Committee reviewsgranted at year end and makes recommendationshave a term of five years and an exercise price equal to the Board regarding services provided by the independent accountants, reviews with the independent accountants the scope and resultsclosing stock price on date of their annual examinationgrant. QuantRx did not compensate members of the Company's consolidated financial statementsBoard of Directors in 2006 and any recommendations they may have, and makes recommendations2005 prior to the Board with respect to the engagement or dischargeadoption of the independent accountants. The Audit Committee also reviews the Company's procedures with respect to maintaining books and records, the adequacy and implementation of internal auditing, accounting and financial controls, and the Company's policies concerning financial reporting and business practices. The Audit Committee: reviewed and discussed the audited financial statements with management; discussed with the independent auditors the matters required to be discussed under SAS 61; reviewed the written disclosures and the letter from the independent accountants required by Independence Accounting Standards No. 1 and discussed with the independent accountants, the independent accountants' independence; and, based on such review and -4- discussions, recommendedBoard compensation policy. It is anticipated that the audited financial statements be included inBoard of Directors will update and revise Board compensation at an upcoming meeting of the Company's Annual Report on Form 10-KSBBoard of Directors. The following table summarizes Director Compensation for the year ended December 31, 1999. The Board of Directors has adopted a written charter2006. There was no Director Compensation for the Audit Committee, a copy of which is attached to the Proxy Statement as Appendix 1. The Compensation Committee administers the 1994 Plan. The Compensation Committee currently consists of RoseAnna Sevcik, Chair, Carol A. Scott and Merry Disney, who was appointed to the Compensation Committee when she became a member of the Board of Directors. For the year ended December 31, 1999, the Compensation Committee consisted2005.
Fees Earned or Stock Option All Other Paid in Awards Awards Compensation Total Name Cash ($) ($) ($) ($) ($) - ------------------------------------------------------------------------------------------------------- Walter W. Witoshkin - - - - - William H. Fleming - - - - - Evan Levine - - - - - Shalom Hirschman (1) - - $6,938 $48,000 $54,938 Arthur Hull Hayes, Jr. (2) $5,000 - $6,938 - $11,398
(1) Dr. Shalom Hirschman received an option grant at December 29, 2006 for 6,250 common shares. Material terms are as follows: December 29, 2006 grant date, exercise price of Ms. Scott$1.17 and Ms. Sevcik and held one meeting. The Board of Directors held eight meetings during 1999. Each incumbent director serving on the Board of Directors during 1999 was present for more than 75 percent of the aggregate number of (i) all meetings of the Board of Directors held during thea five year while he or she was a director and (ii) all meetings of committees on which he or she served. Directors of A-Fem who are also employed by A-Fem doterm. Dr. Hirschman did not receive additionalcash compensation related to his directorship pursuant to a consulting agreement in effect. (2) Dr. Arthur Hull Hayes, Jr. received an option grant at December 29, 2006 for their services6,250 common shares. Material terms are as directors. Non-employee directorsfollows: December 29, 2006 grant date, exercise price of A-Fem receive compensation$1.17 and a five year term. 9 The Company used the Black-Scholes option price calculation to value the options granted in 2006 using the formfollowing assumptions: risk-free rate of 4.93%; volatility of 1.70; actual term and exercise price of options to purchase A-Fem's common stock. Directors who serve on the committee that administers A-Fem's Amendedgranted. Security Ownership of Certain Beneficial Owners and Restated 1994 Incentive and Non-Qualified Stock Option Plan receive options pursuant to paragraph 13 of the 1994 Plan. James E. Reinmuth, A-Fem's Chairman of the Board receives fees of $30,000 per year for consulting services provided to the Company. MANAGEMENT INFORMATION Executive Compensation Compensation SummaryManagement The following table sets forth certain information regarding the compensation paid to the Chief Executive Officer and any other corporate officers who received in excess of $100,000 in compensation in the fiscal year ended December 31, 1999 (the "Named Executive Officers") for each of the fiscal years ended December 31, 1999, 1998 and 1997.
Summary Compensation Table Long-Term Annual Compensation Compensation ----------------------- ----------------------- Other Annual Securities Underlying Name and Principal Salary Compensation Options/Warrants Position Year ($) ($) (#) - ------------------------------- ------ ---------- ------------ ----------------------- James E. Reinmuth (1) 1999 30,000 - - Chief Executive Officer, 1998 45,025 - 150,000 Chairman and Director 1997 40,000 - 26,667 Steven T. Frankel (2) 1999 300,769 - - Chief Executive Officer, 1998 103,863 - 1,700,000 President and Director 1997 - - - William H. Fleming 1999 115,000 - - Vice Chairman-Diagnostics, 1998 119,449 - 150,000 Secretary and Director 1997 115,000 - 26,667 - -------------------
(1) James E. Reinmuth served as Chief Executive Officer of A-Fem until April 1998. (2) Steven T. Frankel became Chief Executive Officer of A-Fem in April 1998 and President of A-Fem in November 1998. Mr. Frankel's 1999 salary includes $60,769 in deferred salary from 1998. -5- Grant of Stock Options No options were granted to Named Executive Officers during the fiscal year ended December 31, 1999. Exercise of Stock Options and Year-End Option/Warrant Values There were no exercises of stock options by the Named Executive Officers during the fiscal year ended December 31, 1999. The following table sets forth certain information regarding options and warrants of the Named Executive Officers outstanding as of December 31, 1999.
Aggregated Option Exercises in 1999 and Year-End Option/Warrant Values Number of Securities Value of Unexercised Underlying Unexercised In-the-Money Options/Warrants at Options/Warrants at December 31, 1999 December 31, 1999 (2) --------------------------------- -------------------------------- Name Exercisable Unexercisable Exercisable Unexercisable - ------------------- -------------- ----------------- ----------- ------------- James E. Reinmuth 326,667 150,000(1) -0- -0- Steven T. Frankel 475,000 1,225,000(1) -0- -0- William H. Fleming 176,667 150,000(1) -0- -0-
- ------------------- (1) These options are subject to performance-based conditions. (2) Based on a fair market valueMay 9, 2007 concerning the ownership of $.72 per share, the price per share of A-Fem's common stock on December 31, 1999. Employment Agreements A-Fem entered into a consulting agreement with James E. Reinmuth dated effective December 1, 1998 (the "Reinmuth Consulting Agreement"), with respect to Mr. Reinmuth's services as Chairman of the Board. The Reinmuth Consulting Agreement provides for a fee of $2,500 per month. Either party may terminate the Reinmuth Consulting Agreement on 30 days' prior notice. A-Fem entered into an employment agreement with James R. Wilson dated effective May 1, 1997 (the "Wilson Employment Agreement"), with respect to Mr. Wilson's services as A-Fem's Treasurer. The Wilson Employment Agreement provides for a salary of $5,000 per month. Either party may terminate the Wilson Employment Agreement on 30 days' prior notice. A-Fem entered into an employment agreement with Steven T. Frankel dated effective April 25, 1998 (the "Frankel Employment Agreement"), with respect to Mr. Frankel's services as A-Fem's Chief Executive Officer. The Frankel Employment Agreement provides for a salary of $20,000 per month. Either party may terminate the Frankel Employment Agreement on 30 days' prior notice. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT The following table sets forth certain information regarding the beneficial ownership as of December 31, 2000 of the Company's Common Stock by (i) each beneficial owner of more than 5 percent of the Common Stock, (ii) the Named Executive Officers, (iii) each director and director nomineestockholder of the Company and (iv) all directors and executive officers as a group. Each person named inknown by the table has sole investment and voting power with respect to the shares set forth opposite his or her name, except as otherwise noted. -6-
Name and Address of Amount and Nature of Percent of Class Beneficial Owner Beneficial Ownership (1) Outstanding - ------------------------------------------- ------------------------ ---------------- Capital Consultants, LLC 7,976,335 (2) 45.4% 2300 SW First Avenue, Suite 200 Portland, OR 97201 Merry Disney 10,000 (3) * c/o Pacific Group 100 Atlantic Avenue, Suite 409 Long Beach, CA 90802 Director William H. Fleming 791,367 (4) 8.1% Suite J-5 10180 SW Nimbus Avenue Portland, OR 97223-4341 Vice-Chairman, Secretary and Director Steven T. Frankel 487,500 (5) 4.8% Suite J-5 10180 SW Nimbus Avenue Portland, OR 97223-4341 Chief Executive Officer, President and Director James E. Reinmuth 540,667 (6) 5.5% 5171 Solar Heights Drive Eugene, OR 97405 Chairman and Director Richard T. Schroeder 539,000 (7) 5.5% 3840 SW 75th Ave. Portland, OR 97225 Carol A. Scott 60,000 (8) * 1834 Park Blvd. Palo Alto, CA 94306 Director RoseAnna Sevcik 60,000 (9) * 3843 Cottonwood Grove Terrace Calabasas, CA 91301 Director James R. Wilson 410,095 (10) 4.2% 2968 Matt Drive Eugene, OR 97408 Treasurer and Director All directors and officers 2,359,629 (11) 21.8% as a group (8 persons)
- ----------------------- * Less than 1%. -7- (1) "Beneficial Ownership" is defined pursuant to Rule 13d-3 of the Exchange Act, and generally means any person who directly or indirectly has or shares voting or investment power with respect to a security. A person shall be deemedCompany to be the beneficial owner of a security ifmore than 5% of the outstanding shares of common stock, (ii) each current member of the board of directors of the Company and (iii) each executive officer of the Company named in the Summary Compensation Table appearing under "Compensation of Directors and Executive Officers" above. The number and percentage of shares beneficially owned is determined in accordance with Rule 13d-3 of the Securities Exchange Act and the information is not necessarily indicative of beneficial ownership for any other purpose. Under that personrule, beneficial ownership includes any shares as to which the individual or entity has voting power or investment power and any shares that the individual has the right to acquire beneficial ownership of such security within 60 days including, but not limited to, any right to acquire such security through the exercise of any stock option or warrantother right. Unless otherwise indicated in the footnotes or throughtable, each person or entity has sole voting and investment power, or shares such powers with his or her spouse, with respect to the conversionshares shown as beneficially owned. The Company had only common stock outstanding at May 9, 2007; therefore the following table refers to our common stock.
Amount and Nature of Beneficial Ownership as of Name and Address of Beneficial Owner (1) May 9, 2007 Percentage of Class (2) - -------------------------------------------------------------------------------------------------------------- Walter W. Witoshkin (3) 833,236 2.00% William H. Fleming 492,034 1.20% Arthur Hull Hayes, Jr. (4) 6,250 * Shalom Hirschman (5) 506,250 1.24% Evan Levine (6) 3,970,220 9.67% 6725 Mesa Ridge Road, Suite 100 San Diego, CA 92121 Sasha Afanassiev (7) 100,000 0.24% Matthew Balk (8) 5,728,009 14.00% 570 Lexington Avenue New York, NY 10021 Mark Capital, LLC (9) 2,945,000 7.17% 6725 Mesa Ridge Road, Suite 100 San Diego, CA 92121 Sherbrooke Partners, LLC 4,508,009 11.02% 570 Lexington Avenue New York, NY 10021
(1) Unless indicated otherwise, the address of a security. Any securities noteach person listed in the table is: c/o QuantRx Biomedical Corporation, 100 South Main Street, Suite 300, Doylestown, Pennsylvania 18901. (2) The percentage of beneficial ownership of common stock is based on 40,910,580 shares of common stock outstanding that are subject to suchas of May 9, 2007 and excludes all shares of common stock issuable upon the exercise of outstanding 10 options or warrants shall be deemed to be outstanding for the purpose of computing the percentage of outstanding securities of the class owned by such person, but shall not be deemed to be outstanding for the purpose of computing the percentage of the class owned by any other person. (2) Includes 7,492,135 shares issuable uponpurchase common stock or conversion of any common stock equivalents, other than the shares of Series A Stock, and an additional 484,200 shares issuable upon conversion of shares issuable upon exercise of warrants to purchase Series A Stock. Capital Consultants LLC acts as an agent for individual investors with respect to all shares beneficially owned by it. Capital Consultants LLC is an investment advisor registered under Section 203 of the Investment Advisors Act of 1940 and has, on behalf of certain of its clients, sole voting power and sole investment power with respect to certain of these shares. (3) Consists of 10,000 shares issuable upon exercise of options to purchase Common Stock. (4) Includes 176,667 sharescommon stock issuable upon the exercise of options or warrants to purchase Common Stock.common stock held by the named person to the extent such options or warrants are exercisable within 60 days of May 9, 2007. (3) Ownership is based upon 796,181 common stock options currently exercisable and 37,055 common stock options exercisable within 60 days of May 9, 2007. (4) Ownership is based on 6,250 currently exercisable common stock options. (5) Consists of 487,500 shares issuable upon the exercise of options to purchase Common Stock.Ownership includes 6,250 currently exercisable common stock options. (6) Includes 23,0002,765,000 shares of common stock and a common stock warrant currently exercisable for 180,000 common shares held by Mark Capital, LLC of which Evan Levine is the managing member; 990,000 shares of common stock held by the Reinmuth Family Trust, 23,000Mr. Levine as custodian for his two children; and 35,220 shares held by Terry A. Reinmuth, 4,000 shares held by Hilary J. Reinmuth, 4,000 shares held by Jennifer C. Reinmuth, 250,000 shares issuable upon exercise of a warrant to purchase Common Stock and 76,667 shares issuable upon exercise of options to purchase Common Stock. (7) Includes 200,000 shares issuable upon the exercise of warrants to purchase Common Stock, 30,000 sharescommon stock held by Mr. Schroeder's spouse, and 29,000Levine's retirement plan. (7) Ownership is based on 100,000 common stock options currently exercisable. (8) Includes 4,508,009 shares of common stock held by their children. Mr. Schroeder disclaims beneficial ownershipSherbrooke Partners, LLC, of which Matthew Balk is the 29,000sole member; and 1,220,000 shares of common stock held by Mr. Balk as custodian for his two children. (8) Includes 60,000 shares issuable upon the exercise of options to purchase Common Stock. (9) Includes 60,000 shares issuable upon the exercise of options to purchase Common Stock. (10) Includes 160,000 shares of Common Stock held jointly with Mr. Wilson's spouse, 153,428 shares with respect to which Mr. Wilson shares voting power with his spouse, and 96,667 shares issuable upon the exercise of options to purchase Common Stock. (11) Includes 967,501 shares issuable upon the exercise of options to purchase Common Stock and 250,000 shares issuable upon exercises ofOwnership includes 180,000 common stock warrants to purchase Common Stock. Section 16(a) Beneficial Ownership Reporting Compliancecurrently exercisable for 180,000 common shares. *Less than .02% SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE Section 16(a) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), requires that the Company's officers, directorsDirectors and Officers, and persons who own more than 10 percent10% of a registered class of the Common StockCompany's equity securities ("Section 16 Persons"), to file with the Securities and Exchange Commission (the "SEC")SEC initial reports of beneficial ownership on Form 3 and reports of changes in beneficial ownership of Common Stockcommon stock and other equity securities of the Company on Form 4. Officers, directors, and greater than 10 percent stockholders of the CompanyCompany. Section 16 Persons are required by SEC regulationsregulation to furnish to the Company with copies of all Section 16(a) reports that they file. ForBased on the year ended December 31, 1999,Company's review of the forms it has received, on other reports filed by Section 16 Persons with the SEC and on the Company's records, the Company believes that during 2006, (1) Arthur Hull Hayes, Jr. did not timely file a Form 3 to report no beneficial ownership of securities, (2) Cynthia Horton did not timely file a Form 3 to report the beneficial ownership of 100,000 common stock options, (3) William H. Fleming did not timely report three transactions and failed to file a Form 5 for such year. Mr. Fleming has reported these delinquencies on4 to report the grant of 100,000 common stock options, (4) Sasha Afanassiev did not timely file a Form 4 he filed for June 2000. Toto report the Company's knowledge, based solely on reviewsgrant of such reports furnished25,000 common stock options, (5) Shalom Hirschman did not timely file a Form 4 to report the Companygrant of 6,250 common stock options, (6) Arthur Hull Hayes, Jr. did not timely file a Form 4 to report the grant of 6,250 common stock options, (7) Evan Levine did not timely file a Form 3 to report the beneficial ownership of our capital stock, and written representations that no other reports are required, all other Section 16(a) filing requirements applicable(8) Matthew Balk did not timely file a Form 3, as a more than 10% owner, to its officers, directors and greater than 10 percentreport the beneficial owners were complied with on a timely basis for fiscal year ended December 31, 1999. Certain Relationships and Related Transactions Asownership of December 31, 1999, William H. Fleming, A-Fem's Vice-Chairman of the Board and Secretary, had an outstanding balance of approximately $66,000 on a loan from A-Fem. This loan was made on November 18, 1994, and the -8- original principal balance was $52,000. Interest accrues at a rate of 6.24 percent and is capitalized. Mr. Fleming used the proceeds from this loan to purchase shares of A-Fem's Common Stock upon exercise of a stock option. Mr. Fleming and the Company have agreed that the outstanding balance on this loan shall become due and payable on July 1, 2001, and that Mr. Fleming may make such payment by transferring to the Company shares of the Company's Common Stock that he owns with a value equal to such outstanding balance on the date of repayment.our capital stock. PROPOSAL NO. 2 - APPROVAL OF AMENDMENT TO THE ARTICLES TO INCREASE THE AUTHORIZED NUMBER OF SHARES OF THE COMPANY'S COMMON STOCK AND PREFERRED STOCK The Company's Articles currently authorize issuance of 43,000,000 shares of capital stock, consisting of 33,000,000 shares of Common Stock and 10,000,000 shares of Preferred Stock. The Board of Directors has adopted a resolution to amend the Articles to increase the authorized capital stock of the Company to 100,000,000 shares by increasing the number of authorized shares of Common Stock to 75,000,000 shares and increasing the number of authorized shares of Preferred Stock to 25,000,000. The text of the Amendment to the Articles is set forth as Appendix 1 to the Proxy Statement. The additional authorized shares of Common Stock and Preferred Stock will not have preemptive rights. The other terms of the additional authorized shares of Preferred Stock cannot be stated or estimated at this time because no offering of the Preferred Stock is contemplated in the proximate future. The Board of Directors will have the authority to fix and determine the rights and preferences of the shares of any series of Preferred Stock which is established, including dividends, conversion prices, voting rights, redemption prices, maturity dates and similar matters, without further action by the stockholders. The Company must obtain the approval of the holders of a majority of the outstanding shares of Series A Stock to issue additional shares of Preferred Stock. Publicly held companies, such as the Company, need to have a sufficient number of authorized shares of Common Stock and Preferred Stock available to be issued from time to time in order to respond to financing needs. The Board of Directors believe it is in the Company's interest to have a variety of financing alternatives available to allow the Company to address its capital requirements in rapidly changing capital markets. The potential issuance of Preferred Stock may have the effect of delaying, deferring or preventing a change in control of the Company, may discourage bids for the Common Stock at a premium over the market price of the Common Stock and may adversely affect the market price of, and the voting and other rights of the holders of, Common Stock. The Company has no current plans to issue additional shares of Preferred Stock. The Company is governed by Nevada law, including the provisions of Chapter 78 of Nevada Revised Statutes. In general, Section 78.438 prohibits a resident domestic Nevada corporation from engaging in a "combination" with an "interested stockholder" for a period of three years after the date of the transaction in which the person became an interested stockholder, unless the combination is approved in a prescribed manner. "Combination" includes mergers, asset sales and other transactions resulting in a financial benefit to the interested stockholder. An "interested stockholder" is a person who is the beneficial owner, directly or indirectly, of 10 percent or more of the corporation's voting stock or who is an affiliate or associate of the corporation and at any time within three years prior to the date in question was the beneficial owner, directly or indirectly, of 10 percent or more of the corporation's voting stock. THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR APPROVAL OF THE AMENDMENT TO THE ARTICLES TO INCREASE THE AUTHORIZED NUMBER OF SHARES OF THE COMPANY'S COMMON STOCK AND PREFERRED STOCK. -9- PROPOSAL NO. 3 - APPROVAL OF AMENDMENT TO THE COMPANY'S AMENDED AND RESTATED 1994QUANTRX 2007 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN The 2007 Incentive and Non-Qualified Stock Option Plan is Attached Hereto as Exhibit C. The description below of the 2007 Incentive and Non-Qualified Stock Option Plan is qualified in its entirety by reference to the complete text of the 2007 Incentive and Non-Qualified Stock Option Plan. Terms not defined herein shall have the meanings set forth in the 2007 Incentive and Non-Qualified Stock Option Plan. The Board proposes that at the Annual Meeting the Stockholders approve the 2007 Incentive and Non-Qualified Stock Option Plan. Recommendation THE BOARD UNANIMOUSLY RECOMMENDS A VOTE FOR THE RATIFICATION OF THE 2007 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN. Description of 2007 Incentive and Non-Qualified Stock Option Plan 11 The Boardpurpose of Directors has adopted a resolution amendingthis Plan is to advance the 1994 Plan to increase the number of shares of Common Stock reserved for issuance under the 1994 Plan to 5,100,000 shares, subject to stockholder approval. A copy of the 1994 Plan, as amended to incorporate the proposed amendment, is attached to this Proxy Statement as Appendix 3. Before this increase, an aggregate of 3,300,000 shares (subject to adjustment by reason of any reorganization, merger, consolidation, plan of recapitalization, reclassification, stock split-up, combination of shares or dividends payable in shares of the Company's Common Stock) was reserved for issuance pursuant to awards under the 1994 Plan. As of December 31, 2000, an aggregate of 1,530,090 shares were subject to outstanding stock options and 522,130 shares were available for grant. The exercise prices for currently outstanding stock options range from $0.78 to $5.13 per share. Options for 1,247,780 shares have been exercised under the 1994 Plan. Under the 1994 Plan, the Company may grant incentive stock options (ISOs), nonqualified stock options (NSOs), stock bonuses, restricted stock, stock appreciation rights, cash bonus rights, performance units, foreign qualified grants and formula awards, separately or in combination. No grants of stock bonuses, restricted stock, stock appreciation rights, cash bonus rights, performance units, foreign qualified grants or formula awards have been made under the 1994 Plan. Eligibility Awards may be granted under the 1994 Plan to selected employees, officers, directors, nonemployee agents, consultants, advisors, persons involved in the sale or distribution of the Company's products and independent contractors of the Company; provided, however, that only employees of the Company may be awarded ISOs. As of December 31, 2000, approximately 11 persons were eligible to receive awards under the 1994 Plan. Since awards under the 1994 Plan are discretionary, awards thereunder for the 2001 fiscal year are not currently determinable. In the fiscal year ended December 31, 2000, options to purchase an aggregate of 30,000 shares at an exercise price of $1.00 per share and 10,000 shares at an exercise price of $3.13 per share of Common Stock were granted to Merry Disney and Rose Anna Sevcik respectively, each a directorinterests of the Company and optionsits Related Entities by providing an additional incentive to purchase an aggregate of 362,500 shares of Common Stock were grantedattract and retain qualified and competent persons who provide services to employeesthe Company and its Related Entities, and upon whose efforts and judgment the success of the Company at an exercise priceand its Related Entities is largely dependent, through the encouragement of $0.78 per share. Administrationstock ownership in the Company by such persons. The 1994 Plan maywill be administered by the Company's Board of Directors or the Compensation Committee approved by the Board of Directors (the "Plan Administrator"). The 1994 Plan is currently administered by a Committee of the Board of Directors, which has the authority, subject to the provisions of the 1994 Plan, to determine the persons to whom awards will be made and the size and terms of the awards. Terms and Conditions of Options Options granted under the 1994 Plan may be ISOs or NSOs. The Plan Administrator determines the number of shares subject to the option, the option price, the period of the option, the exercise time and whether an option is an ISO or NSO; provided, however, that with regard to ISOs, the aggregate fair market value of shares (determined at the time the ISO is granted) with respect to which ISOs are exercisable for the first time by an employee during any calendar year may not exceed $100,000. With regard to ISOs, the exercise price cannot be less than the fair market value of the Common Stock on the date of grant or 110 percent of such fair market value in the case of ISOs granted to individuals who hold 10 percent or more of the Common Stock on the date of grant. Upon exercise of any option, payment for shares as to which an option is being exercised may be made in cash, or with the consent of the Board, in shares of the Company's Common Stock valued at fair market value, restricted stock, performance or other contingent awards denominated in either stock or cash, promissory notes and other forms of consideration. -10- No option will be exercisable more than 10 years from the date on which it is granted and an ISO granted to any individual who holds 10 percent or more of the Common Stock on the date of grant will not be exercisable more than five years from the date on which it is granted. Options granted under the 1994 Plan are non-transferable by any optionee other than by will or the laws of descent and distribution or, with respect to NSOs, as otherwise determined by the Plan Administrator or pursuant to a qualified domestic relations order as defined in the U.S. Internal Revenue Code (the "Code") or the Employee Retirement Income Security Act of 1974, as amended ("ERISA"). Stock Bonuses The Plan Administrator is authorized to award shares to participants on such terms and conditions and subject to such restrictions, if any (whether based on period of service or performance goals), as the Plan Administrator may determine. Restrictions may include restrictions concerning transferability and forfeiture of the shares awarded. The Plan Administrator may require the recipient to sign an agreement as a condition of the award, but may not require monetary consideration other than amounts necessary to satisfy any tax withholding requirements. Restricted Stock The Plan Administrator may issue shares of restricted stock under the 1994 Plan for such consideration (including promissory notes and services) as determined by the Plan Administrator. All restricted stock issued will be subject to a purchase agreement which will be executed by the Company and the prospective recipientcomposed of the shares and may contain any terms, conditions, restrictions, representations and warranties required by the Plan Administrator.two or more Directors. The restrictions may include limitations concerning transferability, repurchase by the Company and forfeituremembership of the shares issued. Stock Appreciation Rights A stock appreciation right gives its holder the right to receive, upon exercise, an amount equal in value to the excess of the fair market value on the date of exercise of one share of Common Stock over its fair market value on the date of grant, multiplied by the number of shares covered by the stock appreciation right that is surrendered. The appreciation distribution may be paid in Common Stock valued at fair market value, in cash, or partly in Common Stock and partly in cash, as determined by the Plan Administrator. The Plan Administrator may withdraw any stock appreciation right granted under the 1994 Plan at any time and may impose any conditions upon the exercise of the stock appreciation right. The provisions of the 1994 Plan regarding nontransferability of options apply equally to stock appreciation rights. Cash Bonus Rights Cash bonus rights may be granted under the 1994 Plan in connection with options, stock appreciation rights, stock bonuses and shares sold under the 1994 Plan. Cash bonus rights will be subject to rules, terms and conditions as the Plan Administrator may prescribe. A cash bonus right granted in connection with an option will entitle an optionee to a cash bonus when the related option is exercised in whole or in part. A cash bonus right granted in connection with a stock bonus or stock purchase will entitle the recipient to a cash bonus payable when the stock bonus is awarded or when shares are purchased, respectively, or when restrictions, if any, to which the stock is subject lapse. Performance Units The Plan Administrator may grant performance units consisting of monetary units which may be earned in whole or in part if the Company achieves certain goals established by the Plan Administrator over a designated period of time not to exceed 10 years. The goals established by the Plan Administrator may include earnings per share, return on stockholders' equity, return on invested capital and such other goals as may be established by the Plan Administrator. Payment of an award earned may be in cash or in Common Stock or a combination of both, and may be made when earned, or vested and deferred, as the Plan Administrator determines. The provisions of the 1994 Plan regarding nontransferability of options applies equally to performance units. -11- Foreign Qualified Grants Awards under the 1994 Plan may be awarded to qualified persons residing in foreign jurisdictions as the Plan Administrator may determine from time to time. The Plan Administrator may adopt such supplements to the 1994 Plan as may be necessary to comply with the applicable laws of such foreign jurisdictions and to afford participants favorable treatment under such laws. Formula Awards Each director appointed to the Committee will be granted NSOsconstituted so as to comply at all times with the then applicable requirements for 30,000 sharesOutside Directors of Common Stock ("Formula Options") on the date such director is appointed and further grants of NSOs for 30,000 shares of Common Stock on the third anniversary of the grant of such member's most recent grant; provided, however, that the grant to a newly appointed member will be reduced on an option-for-option basis by the amount of any option grants accepted by such appointee from the Company within the prior 24-month period. The Formula Options will have an exercise price per share equal to the fair market value of Common Stock on the date of grant and will vest in three equal installments on each of the first three anniversaries of the date of grant. Amendment and Acceleration The 1994 Plan may be amended at any time by the Plan Administrator, subject to approval by stockholders of any amendment that (i) materially increases the total number of shares subject to the 1994 Plan; (ii) materially modifies the class of eligible employeesRule 16b-3 promulgated under the 1994 Plan; or (iii) effects a change relating to ISOs that is inconsistent with the Code, ERISA, or the rulesSecurities Exchange Act and regulations adopted thereunder. All options and stock appreciation rights outstanding under the 1994 Plan will become exercisable in full for the remainder of their terms upon certain events, including a consolidation, merger or plan of exchange involving the Company pursuant to which Common Stock is converted into cash; any sale, lease, exchange or other transfer of all or substantially all the assets of the Company; any tender or exchange offer other than by the Company in which at least 20 percent of the outstanding Common Stock is purchased; and certain changes in the equity ownership of the Company or composition of the Board of Directors. Federal Income Tax Consequences The following discussion summarizes the material federal income tax consequences of participation in the 1994 Plan. The discussion is general in nature and does not address issues related to the tax circumstances of any particular participant in the 1994 Plan. The discussion is based on federal income tax laws in effect on the date hereof and is, therefore, subject to possible future changes in law. The discussion does not address state, local or foreign tax consequences. Under present law and regulations, no income will be recognized by a participant upon the grant of stock options, stock appreciation rights, and other stock-based awards or performance awards under the 1994 Plan. Non-Qualified Stock Options. Upon the exercise of an NSO, an optionee recognizes taxable ordinary income equal to the difference between the exercise price for the shares and the fair market value of the shares on the date of exercise. Incentive Stock Options. An optionee does not recognize income upon the exercise of an ISO, except that the excess of the fair market value of the shares at the time of exercise over the option price will be income for purposes of calculating the optionee's alternative minimum tax, if any. An option loses its status as an ISO if the optionee exercises the ISO (i) more than three months after the optionee terminates employment or retires for reasons other than death or disability or (ii) more than one year after the optionee terminates employment because of disability. If an optionee does not make a "disqualifying disposition" (defined below) of an ISO, the gain, if any, upon a subsequent sale (i.e., the excess of the proceeds received over the option price) will be long-term capital gain. For shares acquired through exercise of an ISO, a "disqualifying disposition" is a transfer of the shares (i) within two years after the grant of the ISO or (ii) within one year after the transfer of the shares to the optionee pursuant to the ISO's exercise. If the optionee makes a disqualifying disposition, the optionee generally will recognize income in the year of the disqualifying disposition equal to the excess of the amount received for the shares over the option price. Of that income, the portion equal to the excess of the fair market value of the shares at the time the ISO was exercised over the option price will -12- be ordinary income and the balance, if any, will be long-term or short-term capital gain, depending on whether the shares were sold more than one year after the ISO was exercised. If, however, the optionee sells the shares to an unrelated party at a price that is below the fair market value of the shares at the time the ISO was exercised and the sale is a disqualifying disposition, the amount of ordinary income will be limited to the amount realized on the sale over the option price. Restricted Stock Awards. A participant who receives an award of restricted stock under the 1994 Plan generally will recognize ordinary income at the time at which the restrictions on such shares (the "Restrictions") lapse, in an amount equal to the excess of (i) the fair market value of such shares at the time the Restrictions lapse, over (ii) the price, if any, paid for such shares. If the participant makes an election with respect to such shares under Section 83(b) of the Code not later than 30 days after the date shares are transferred to the participant pursuant to such award, the participant will recognize ordinary income at the time of transfer in an amount equal to the excess of (i) the fair market value of the shares covered by the award (determined without regard to any restriction other than a restriction which by its terms will never lapse) at the time of such transfer over (ii) the price, if any, paid for such shares. A participant's tax basis in shares received pursuant to a restricted stock award granted under the 1994 Plan will be equal to the sum of the price paid for such shares, if any, and the amount of ordinary income recognized by such participant with respect to the transfer of such shares or the lapse of the Restrictions thereon. The participant's holding period for such shares for purposes of determining gain or loss on a subsequent sale will begin immediately after the transfer of such shares to the participant, if a Section 83(b) election is made with respect to such shares, or immediately after the Restrictions on such shares lapse, if no Section 83(b) election is made. If, subsequent to the lapse of Restrictions on his or her shares, the participant sells such shares, the difference, if any, between the amount realized from such sale and the tax basis of such shares to the holder will be taxed as long-term or short-term capital gain or loss, depending on whether the participant's holding period for such shares exceeds the applicable holding period at the time of sale and provided that the participant holds such shares as a capital asset at such time. If a Section 83(b) election is made and, before the Restrictions on the shares lapse, the shares that are subject to such election are resold to the Company or are forfeited, (i) no deduction would be allowed to such participant for the amount included in the income of such participant by reason of such Section 83(b) election and (ii) the participant would realize a loss in an amount equal to the excess, if any, of the amount paid for such shares over the amount received by the participant upon such resale or forfeiture (which loss would be a capital loss if the shares are held as a capital asset at such time). In such event, the Company would be required to include in its income the amount of any deduction previously allowable to it in connection with the transfer of such shares. Other Awards. Upon payment to a participant in settlement of a stock option or pursuant to the exercise of stock appreciation rights or pursuant to other stock-based awards or a performance award, the participant will recognize taxable ordinary income in an amount equal to the cash and/or fair market value of the Common Stock received. Special rules apply to a director or officer subject to liability under Section 16(b) of the Exchange Act. In all the foregoing cases the Company will be entitled to a deduction at the same time and in the same amount as the participant recognizes ordinary income, subject to the following limitations. Under Section 162(m) of the Code, certain compensation payments in excess of $1 million are subject to a limitation on deductibilityCode. The Committee will serve at the pleasure of the Company. The limitation on deductibility applies with respectBoard and will have the powers designated in the 2007 Incentive and Non-Qualified Stock Option Plan and such other powers as the Board may from time to that portion of a compensation payment for a taxable year in excess of $1 million to either the Company's Chief Executive Officer or any one of the other four most highly compensated executive officers. Certain performance-based compensation is not subject to the limitation on deductibility. Options and stock appreciation rights can qualify for this performance-based exception, but only if they are granted at fair market value, the total number of shares that can be granted to an executive for any period is stated, and stockholder and Board approval is obtained. Restricted stock does not satisfy the definition of performance-based compensation unless the lapse of the restriction period is based on the attainment of specified performance goals approved by the Company's stockholders. The option, stock appreciation right and performance award portions of the 1994 Plan have been drafted to allow compliance with those performance-based criteria. As of January 16, 2001, the last reported sales price per share of Common Stock as reported on the OTC Bulletin Board was $1.00. -13-time confer upon it. 12 THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR APPROVAL OF THE AMENDED AND RESTATED 1994 PLAN TO INCREASE THE NUMBER OF SHARES OF COMMON STOCK RESERVED FOR ISSUANCE UNDER THE 1994 PLAN. PROPOSAL NO. 43 - RATIFICATION OF THE APPOINTMENT OF INDEPENDENT PUBLIC ACCOUNTANTS The Board of Directors will requestproposes that at the stockholdersAnnual Meeting the Stockholders ratify the appointment of Arthur Andersen LLPWilliams & Webster, P.S. as independent public accountants to examine the financial statements of the Company for the fiscal year ending December 31, 2001.2007. RECOMMENDATION THE BOARD UNANIMOUSLY RECOMMENDS A VOTE FOR THE RATIFICATION OF THE APPOINTMENT OF WILLIAMS & WEBSTER, P.S. AS INDEPENDENT PUBLIC ACCOUNTANTS OF THE COMPANY. INDEPENDENT PUBLIC ACCOUNTANTS The Company engaged Williams & Webster, P.S. to serve as the Company's independent public accountants for the fiscal year ended December 31, 2006. A representative of Arthur Andersen LLPWilliams & Webster, P.S. will be presentavailable at the Specialannual Meeting, and will have an opportunity to make a statement if he or she desires to do so and will be available to respond to appropriate questions from stockholders. Audit Fees.Fees The aggregate fees billed for professional services rendered by Williams & Webster, P.S. for the audit of the Company's annual and quarterly financial statements and review of financial statements included in the Company's Forms 10-QSB for years 2006 and 2005 are set forth in the yeartable below. 2006 2005 ---- ---- Williams & Webster, P.S. $39,749 $31,598 Audit-Related Fees During the years ended December 31, 19992006 and 2005, no assurance or related services were $26,000. All Other Fees. The aggregate fees billed for services renderedperformed by Arthur Andersen LLP forWilliams & Webster P.S. that were reasonably related to the yearperformance of the audit or review of the Company's financial statements. Tax Fees During the years ended December 31, 1999,2006 and 2005, $6,000 and $0 in fees were billed by Williams & Webster, P.S. for tax compliance, tax advice or tax planning services. All Other Fees During the years ended December 31, 2006 and 2005, no fees were billed by Williams & Webster, P.S. other than the audit fees disclosed above, were $5,750. Forset forth under the year ended December 31, 1999,caption "Audit Fees" above. Pre-approval Policies and Procedures of the Audit Committee The Audit Committee has the sole authority to appoint, terminate and replace the Company's independent auditor. The Audit Committee didmay not consider whetherdelegate these responsibilities. The Audit Committee has the provisionsole authority to approve the scope, fees and terms of all audit engagements, as well as all permissible non-audit engagements of the Company's independent auditor. 100% of the services unrelated toprovided by Williams & Webster, P.S. were pre-approved by the audit was compatible with maintaining the principal accountant's independence. THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE RATIFICATION OF THE APPOINTMENT OF ARTHUR ANDERSEN LLP AS INDEPENDENT PUBLIC ACCOUNTANTS OF THE COMPANY.Audit Committee. 13 PROPOSALS OF STOCKHOLDERS Any stockholder wishing to have a proposal considered for inclusion in the proxy materials for the Company's 2001 annual meeting2007 Annual Meeting of stockholdersStockholders must set forth such proposal in writing and file it with the Secretary of the Company no later than a reasonable time before the Company begins to print and mail its proxy materials for the Company's 2001 annual meeting2007 Annual Meeting of stockholders.Stockholders. In addition, if the Company receives notice of a shareholder proposal later than a reasonable time before the Company mails its proxy materials for the Company's 2001 annual meeting2007 Annual Meeting of stockholders,Stockholders, the persons named as proxies in the proxy statement and accompanying proxy will have discretionary authority to vote on that shareholder proposal. INCORPORATION BY REFERENCE The Financial Statements and the Management's Discussion and Analysis of Financial Condition and Results of Operations contained in the Company's Annual Report to Stockholders for the fiscal year ended December 31, 1999,2006, transmitted with the Proxy Statement,proxy statement, are hereby incorporated by reference. No other portions of the Annual Report shall be deemed incorporated herein. You may obtain documents incorporated by reference from the Securities and Exchange Commission's website, www.sec.gov, or directly from us, without charge, by requesting them in writing or by telephone at: QuantRx Biomedical Corporation 100 South Main Street, Suite 300 Doylestown, Pennsylvania 18901 (267) 880-1595 If you would like to request additional copies of this document or any of the documents incorporated by reference, please do so at least five business days before the date of the annual meeting in order to receive timely delivery of such documents. FINANCIAL INFORMATION THE COMPANY'S 19992006 ANNUAL REPORT TO STOCKHOLDERS ACCOMPANIES THESE MATERIALS. COPIES OF THE COMPANY'S ANNUAL REPORT ON FORM 10-KSB FOR THE FISCAL YEAR ENDED DECEMBER 31, 19992006 MAY BE OBTAINED FROM THE COMPANY WITHOUT CHARGE UPON WRITTEN REQUEST TO THE COMPANY. REQUESTS SHOULD BE DIRECTED TO THE CONTROLLER, A-FEM MEDICALCHIEF FINANCIAL OFFICER, QUANTRX BIOMEDICAL CORPORATION, 10180 S.W. NIMBUS AVENUE,100 SOUTH MAIN STREET, SUITE J-5, PORTLAND, OREGON 97223.300, DOYLESTOWN, PENNSYLVANIA 18901. By Order of the Board of Directors /s/ Steven T. Frankel -------------------------------------------------------- Steven T. Frankel, PresidentWalter W. Witoshkin ------------------------------------------------ Walter W. Witoshkin, Chairman and Chief Executive Officer February 9, 2001 -14- APPENDIX 1 A-FEM MEDICAL CORPORATION AUDIT COMMITTEE OF THE BOARD OF DIRECTORS CHARTER Adopted August 4, 2000 I. Overall Purpose The primary purpose of the Audit Committee is to assist the Board of Directors in achieving its oversight responsibilities in the following areas: |X| Overseeing that management has maintained the reliability and integrity of the accounting policies and financial reporting and disclosure practices of the Company; |X| Overseeing that management has established and maintained processes to assure that an adequate system of internal control over key business risks is functioning within the Company; |X| Overseeing that management has established and maintained processes to assure compliance by the Company with all applicable laws, regulations and Company policies. II. Composition The Audit Committee shall be comprised of two or more directors as determined by the Board, each of whom shall be independent directors, and free from any relationship that, in the opinion of the Board, would interfere with the exercise of his or her independent judgment as a member of the Committee. All members of the Committee shall have a working familiarity with basic finance and accounting practices, and at least one member of the Committee shall have accounting or related financial management expertise. The members of the Committee shall be elected by the Board at the annual organizational meeting of the Board and will serve until their successors shall be duly elected and qualified. Unless a Chair is elected by the full Board, the members of the Committee may designate a Chair by majority vote of the full Committee membership. III. Meetings The Committee shall meet at least quarterly, prior to the Company's release of earnings for the preceding quarter. In addition to the Committee members, Company management and the independent accountants will attend these quarterly meetings. The agenda for the quarterly meetings shall include, at a minimum, a review of the Company's financial results and an executive session with the independent accountants. The Committee will include other agenda topics which, in its opinion, are necessary to executing its responsibilities under this charter. The Committee may meet more frequently as circumstances dictate. IV. Activities In fulfilling its overall purpose, the audit committee shall annually schedule and carry out the following activities. The five broad areas of activities include: |X| General |X| Reporting |X| Independent Accountants |X| Key Risks and Controls |X| Ethical and Legal Standards Activities Area: GENERAL 1. Determine that each Committee member is independent and free from any relationships that would interfere with the exercise of his or her judgment as a member of the Committee. Definition of independence would exclude directors who: Have been employed by the corporation during the past three years, o Accept compensation in excess of $60,000 from the Company, or any of its affiliates during the previous fiscal year other than for board service, benefits under a tax-qualified retirement plan, or non-discretionary compensation, o Are members of the immediate family of any executive officer employed during the past three years, o Are executives of other corporations where any of the corporations executives serves on the compensation committee o Is a partner in, a controlling shareholder or executive officer of any for-profit business organization to which the corporation made or received payments in any of the past three years that exceed 5% of the company's or business organizations consolidated gross revenues for that year, or $200,000, whichever is greater. Payments resulting solely from investments in the company's securities need not be considered for this purpose. 2. Determine that all Committee members are "financially literate" and at least one member has financial management experience, as defined by the full board. 3. Review and update this Charter periodically, at least annually, as conditions dictate. Full board approval is required for adoption and significant changes to the charter. 4. Submit the minutes of all meetings of the audit committee to, or discuss the matters discussed at each meeting with the full Board of Directors. 5. The audit committee shall have the power to conduct or authorize investigations into any matters within the committee's scope of responsibilities. The committee shall be empowered to retain independent counsel, accountants, or others to assist it in the conduct of any investigation. Area: REPORTING 1. Review the Company's annual financial statements and any reports or other financial information submitted to any governmental body, or the public, including any certification, report, opinion, or review rendered by the independent accountants. 2. Review with management and the Company's independent public accountants the applicability and impact of any new pronouncements issued by FASB or other applicable regulatory agencies. 3. Disclose in the annual proxy statement whether the Committee has satisfied its responsibilities in compliance with this charter. Specifically, the report would require audit committees to state that they have reviewed and discussed the financial statements with management, discussed the items required by SAS 61 (including the quality of reporting) with independent auditors, and indicate that the audit committee has received the written report from auditors required by ISB 1 regarding auditors' independence. Finally, the report would require audit committee's to recommend to the Board of Directors that the audited financial statements be included in the Annual Report on Form 10-K for filing with the Commission. 4. Publish the written charter in the annual report at least every three years or in the next proxy statement after a significant amendment. 2 5. Meet with (telephonic or in person) financial management and the independent accountants following the completion of the independent accountants SAS #71 interim financial review and prior to the form 10Q filing/release of earnings. Area: INDEPENDENT ACCOUNTANTS 1. Review and approve the selection of the independent accountants. It should be clear to the independent accountants that they are ultimately accountable to the board of directors and the audit committee as representatives of the shareholders 2. Review with the independent accountants the scope of their examinations of the books and records of the Company and its subsidiaries and direct the special attention of the auditors to specific matters or areas deemed by the Committee or the auditors to be of special significance; and authorizing the auditors to perform such supplemental reviews or audits as the Committee may deem desirable. 3. On an annual basis, receive a formal written statement from the independent auditors as to all significant relationships the accountants have with the Company to determine the accountants' independence. 4. Review with management and the independent auditor their qualitative judgments about the appropriateness, not just the acceptability, of accounting principles and financial disclosure practices used or proposed and, particularly, about the degree of aggressiveness or conservatism of its accounting principles and underlying estimates. 3 5. Review with management and the independent accountants at the completion of their audit: o The existence of any fraud or illegal acts that the auditor may have become aware of; o Any significant deficiencies in the design or operation of internal controls noted during the audit; o Selection of and changes in significant accounting policies or their application; o Process used by management in making significant accounting judgments or estimates o Significant audit adjustments o Review by the auditors of other information in the audited financial statements. o Disagreements with management o Consultation, if any, with other auditors on significant accounting matters Serious difficulties encountered during the audit 6. Consider recommendations from the independent accountants and internal auditors regarding internal controls, information technology controls and security and other matters relating to the Company and its subsidiaries and reviewing the correction of controls or processes deemed to be needing improvement. 7. Provide sufficient opportunity for the independent auditors to meet with the members of the audit committee without members of management present. Among the items to be discussed in these meetings are the independent auditors' evaluation of the Company's financial, accounting, and auditing personnel, and the cooperation that the independent auditors received during the course of the audit. Area: KEY RISKS AND CONTROLS 1. Inquire of management, the independent auditors about significant risks or exposures and assess the steps management has taken to minimize such risks. 2. Review accounting and financial human resources and succession planning. Area: ETHICAL AND LEGAL STANDARDS 1. Review, with the Company's counsel, legal compliance matters including corporate securities trading policies. 2. Perform any other activities consistent with this Charter, the Company's By-laws and governing law, as the Committee or the Board deems necessary or appropriate. 3. Review and approve updates periodically to the Corporations Code of Conduct and ensure that management has established a system to enforce this Code. 4. Perform any other activities consistent with this Charter, the Corporation's By-laws and governing law, as the Committee or the Board deems necessary or appropriate. 4 APPENDIX 2 AMENDMENT TO THE ARTICLES OF INCORPORATION OF A-FEM MEDICAL CORPORATION Section 4.1 of the Articles of Incorporation shall be deleted in its entirety and the following substituted therefor: "4.1 Authorized Capital The corporation is authorized to issue two classes of stock to be designated, respectively, "Common Stock" and "Preferred Stock." The total number of shares of stock that the corporation shall have authority to issue shall be 100,000,000, consisting of 75,000,000 shares of Common Stock with a par value of $.01 per share, and 25,000,000 shares of Preferred Stock with a par value of $.01 per share." 1 APPENDIX 3 A-FEM MEDICAL CORPORATION AMENDED AND RESTATED 1994 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN 1. Purpose. The purpose of this Incentive and Non-Qualified Stock Option Plan (the "Plan") is to enable A-Fem Medical Corporation (the "Company") to attract and retain the services of: (i) selected employees, officers and directors of the Company or of any subsidiary of the Company; and (ii) selected nonemployee agents, consultants, advisors, persons involved in the sale or distribution of the Company's products and independent contractors of the Company or any subsidiary. 2. Shares Subject to the Plan. Subject to adjustment as provided below and in paragraphMay 31, 2007 14 the shares to be offered under the Plan shall consist of Common Stock of the Company, and the total number of shares of Common Stock that may be issued under the Plan shall not exceed 5,100,000 shares. Subject to adjustment from time to time as provided in paragraph 14, not more than 500,000 shares of Common Stock may be made subject to awards under the Plan to any individual participant in the aggregate in any one fiscal year of the Company, such limitation to be applied in a manner consistent with the requirements of, and only to the extent required for compliance with, the exclusion from the limitation on deductibility of compensation under Section 162(m) of the Internal Revenue Code of 1986, as amended (the "Code"). The shares issued under the Plan may be authorized and unissued shares or reacquired shares. If an option, stock appreciation right or performance unit granted under the Plan expires, terminates or is canceled, the unissued shares subject to such option, stock appreciation right or performance unit shall again be available under the Plan. If shares sold or awarded as a bonus under the Plan are forfeited to the Company or repurchased by the Company, the number of shares forfeited or repurchased shall again be available under the Plan. 3. Effective Date and Duration of Plan. (a) Effective Date. This restatement of the Plan shall be effective as of July 10, 1997, the date as of which the Plan was approved by the vote of the holders of a majority of the shares of the Common Stock of the Company. (b) Duration. The Plan shall continue in effect until all shares available for issuance under the Plan have been issued and all restrictions on such shares have lapsed. The Board of Directors may suspend or terminate the Plan at any time except with respect to options, performance units and shares subject to restrictions then outstanding under the Plan. Termination shall not affect any outstanding options, any right of the Company to repurchase shares or the forfeitability of shares issued under the Plan. 4. Administration. The Plan shall be administered by a committee appointed by the Board of Directors of the Company (the "Committee"). If and so long as the Common Stock is registered under Section 12(b) or 12(g) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), the Board of Directors shall consider in selecting members of the Committee, the provisions regarding (a) "outside directors" as contemplated by Section 162(m) of the Code and (b) "nonemployee directors" as contemplated by Rule 16b-3 under the Exchange Act. The Committee shall consist of not fewer than two members of the Company's Board of Directors. The Board of Directors may from time to time remove members from, or add members to, the Committee. Vacancies on the Committee, howsoever caused, shall be filled by the Board of Directors. The Committee shall select one of its members as Chairman, and shall hold meetings at such times and places as it may determine. A majority of the Committee may act at a meeting at which a quorum is present, or acts reduced to or approved in writing by a majority of the members of the Committee shall be the valid acts of the Committee. The Committee shall from time to time at its discretion determine: (i) those Officers, Directors, employees (including key and non-key), consultants and others who shall be granted options; (ii) the number of shares of stock to be optioned to each; and (iii) subject to the express provisions of the Plan, the terms of all options so granted. Other than "Formula Awards" granted pursuant to paragraph 13, no Director while a member of the Committee shall be eligible to receive an option under the Plan. 1 The interpretation and construction by the Committee of any provision of the Plan or of any option granted under it shall be final unless otherwise determined by the Board of Directors. No member of the Board of Directors or the Committee shall be liable for any action or determination made in good faith with respect to the Plan or any option granted under it. If at any time the Committee shall not be in office, or has fewer than two members, the Board of Directors shall perform the functions of the Committee. If authority is delegated to the Committee, all references to the Board of Directors in the Plan shall mean and relate to the Committee except: (i) as otherwise provided by the Board of Directors; and (ii) only the Board of Directors may amend or terminate the Plan as provided in paragraphs 3 and 17. 5. Types of Awards; Eligibility. The Board of Directors may, from time to time, take the following actions, separately or in combination, under the Plan: (i) grant Incentive Stock Options, as defined in Section 422 of the Code, as provided in paragraphs 6(a) and 6(b); (ii) grant options other than Incentive Stock Options ("Non-Statutory Stock Options") as provided in paragraphs 6(a) and 6(c); (iii) award stock bonuses as provided in paragraph 7; (iv) sell shares subject to restrictions as provided in paragraph 8; (v) grant stock appreciation rights as provided in paragraph 9; (vi) grant cash bonus rights as provided in paragraph 10; (vii) grant performance units as provided in paragraph 11; and (viii) grant foreign qualified awards as provided in paragraph 12. The persons who shall be eligible to receive Incentive Stock Options shall be such Officer-employees and other employees (whether or not they are Directors) of the Company or its subsidiaries as the Committee or, if there is no Committee, the Board of Directors, shall select from time to time. Directors who are not employees, consultants and others, who have a relationship with the Company or its subsidiaries, may only receive Non-Statutory Stock Options. Officers and employees may also receive Non-Statutory Stock Options. An optionee may hold more than one option, but only on the terms and subject to the restrictions hereafter set forth. Members of the Committee, and members of the Board of Directors if there is no Committee, shall only be eligible to receive grants under the Plan pursuant to paragraph 13. At the discretion of the Board of Directors or the Committee, if appointed, an individual may be given an election to surrender an award in exchange for the grant of a new award. 6. Option Grants. (a) General Rules Relating to Options. (i) Terms of Grant. The Board of Directors may grant options under the Plan. With respect to each option grant, the Board of Directors shall determine the number of shares subject to the option, the option price, the period of the option, the time or times at which the option may be exercised and whether the option is an Incentive Stock Option or a Non-Statutory Stock Option. At the time of the grant of an option or at any time thereafter, the Board of Directors may provide that an optionee who exercised an option with Common Stock of the Company shall automatically receive a new option to purchase additional shares equal to the number of shares surrendered and may specify the terms and conditions of such new options. (ii) Exercise of Options. Except as provided in paragraph 6(a)(iv) or as determined by the Board of Directors, no option granted under the Plan may be exercised unless at the time of such exercise the optionee is employed by or is in the service of the Company or any subsidiary of the Company and shall have been so employed or have provided such service continuously since the date such option was granted. Absence on leave or on account of illness or disability under rules established by the Board of Directors shall not, however, be deemed an interruption of employment or service for this purpose. Unless otherwise determined by the Board of Directors, if the optionee does not exercise an option in any one year with respect to the full number of shares to which the optionee is entitled in that year, the optionee's rights shall be cumulative and the optionee may purchase those shares in any subsequent year during the term of the option. (iii) Nontransferability. Each Incentive Stock Option and, unless otherwise determined by the Board of Directors with respect to an option granted to a person who is neither an Officer nor a Director of the Company, each other option granted under the Plan by its terms shall be nonassignable and nontransferable by the optionee, either voluntarily or by 2 operation of law, except by will or by the laws of descent and distribution of the state or country of the optionee's domicile at the time of death or, for options other than Incentive Stock Options, pursuant to a qualified domestic relations order as defined under the Code or Title I of the Employee Retirement Income Security Act of 1974, as amended ("ERISA"). (iv) Termination of Employment or Service. (A) General Rule. Unless otherwise determined by the Board of Directors, in the event the employment or service of the optionee with the Company or subsidiary terminates for any reason other than because of physical disability or death as provided in subparagraphs 6(a)(iv)(B) and (C), the option may be exercised at any time prior to the expiration date of the option, but if the option is an Incentive Stock Option, it may not be exercised more than three months following termination of employment. Any option may be exercised only if and to the extent the optionee was entitled to exercise the option at the date of such termination. (B) Termination Because of Total Disability. Unless otherwise determined by the Board of Directors, in the event of the termination of employment or service of the optionee with the Company or a subsidiary because of total disability, the option may be exercised at any time prior to the expiration date of the option, but if the option is an Incentive Stock Option, it must be exercised not more than one year after termination of employment. The term "total disability" means a mental or physical impairment that is expected to result in death or that has lasted or is expected to last for a continuous period of 12 months or more and that causes the optionee to be unable, in the opinion of the Company and two independent physicians, to perform his or her duties as an employee, Director, Officer or consultant of the Company and to be engaged in any substantial gainful activity. Total disability shall be deemed to have occurred on the first day after the Company and the two independent physicians have furnished their opinions of total disability to the Company. (C) Termination Because of Death. Unless otherwise determined by the Board of Directors, in the event of the death of an optionee while employed by or providing service to the Company or a subsidiary, the option may be exercised at any time prior to the expiration date of the option, but only if and to the extent the optionee was entitled to exercise the option at the date of death and only by the person or persons to whom such optionee's rights under the option shall pass by the optionee's will or by the laws of descent and distribution of the state or country of domicile at the time of death. (D) Amendment of Exercise Period Applicable to Termination. The Board of Directors, at the time of grant or at any time thereafter, may increase the portion of an option that is exercisable, subject to such terms and conditions as the Board of Directors may determine. (E) Failure to Exercise Option. To the extent that the option of any deceased optionee or of any optionee whose employment or service terminates is not exercised within the applicable period, all further rights to purchase shares pursuant to such option shall cease and terminate. (v) Purchase of Shares. Unless the Board of Directors determines otherwise, shares may be acquired pursuant to an option granted under the Plan only upon receipt by the Company of notice in writing from the optionee of the optionee's intention to exercise, specifying the number of shares as to which the optionee desires to exercise the option and the date on which the optionee desires to complete the transaction, and if required in order to comply with the Securities Act of 1933, as amended, containing a representation that it is the optionee's present intention to acquire the shares for investment and not with a view to distribution. Unless the Board of Directors determines otherwise, on or before the date specified for completion of the purchase of shares pursuant to an option, the optionee must have paid the Company the full purchase price of such shares in cash (including, with the consent of the Board of Directors, cash that may be the proceeds of a loan from the Company) or, with the consent of the Board of Directors, in whole or in part, in Common Stock of the Company valued at fair market value, restricted stock, performance units or other contingent awards denominated in either stock or cash, promissory notes and other forms of consideration. No shares shall be issued until full payment for the shares has been made. With the consent of the Board of Directors, an optionee may request the Company to apply automatically the shares to be received upon the exercise of a portion of a stock option (even though stock certificates have not yet been issued) to satisfy the purchase price for additional 3 portions of the option. Each optionee who has exercised an option shall immediately upon notification of the amount due, if any, pay to the Company in cash amounts necessary to satisfy any applicable federal, state and local tax withholding requirements. If additional withholding is or becomes required beyond any amount deposited before delivery of the certificates, the optionee shall pay such amount to the Company on demand. If the optionee fails to pay the amount demanded, the Company may withhold that amount from other amounts payable by the Company to the optionee, including salary, subject to applicable law. With the consent of the Board of Directors, an optionee may satisfy this obligation, in whole or in part, by having the Company withhold amounts due or by delivering to the Company Common Stock shares that would satisfy the withholding amount. Upon the exercise of an option, the number of shares reserved for issuance under the Plan shall be reduced by the number of shares issued upon exercise of the option. (b) Incentive Stock Options. Incentive Stock Options shall be subject to the following additional terms and conditions: (i) Limitation of Amount of Grants. No employee may be granted Incentive Stock Options under the Plan if the aggregate fair market value, on the date of grant, of the Common Stock with respect to which Incentive Stock Options are exercisable for the first time by the employee during any calendar year under the Plan and under any other incentive stock option plan (within the meaning of Section 422 of the Code) of the Company or any parent or subsidiary of the Company exceeds $100,000. (ii) Limitation on Grants to 10 Percent Stockholders. An Incentive Stock Option may be granted under the Plan to an employee possessing more than 10 percent of the total combined voting power of all classes of stock of the Company or of any parent or subsidiary of the Company only if the option price is at least 110 percent of the fair market value of the Common Stock subject to the option on the date it is granted, as described in paragraph 6(b)(iv), and the option by its terms is not exercisable after the expiration of five years from the date it is granted. (iii) Duration of Options. Subject to paragraphs 6(a)(ii) and 6(b)(ii), Incentive Stock Options granted under the Plan shall continue in effect for the period fixed by the Board of Directors, except that no Incentive Stock Option shall be exercisable after the expiration of 10 years from the date it is granted. (iv) Option Price. The option price per share shall be determined by the Board of Directors at the time of grant. Except as provided in paragraph 6(b)(ii), the option price shall not be less than 100 percent of the fair market value of the Common Stock covered by the Incentive Stock Option at the date the option is granted. During such time as the Common Stock is not listed upon an established stock exchange, the fair market value per share shall be the mean between the closing "bid" and "ask" prices of the Common Stock in the New York over-the-counter market on the day the option is granted, as reported by the National Association of Securities Dealers, Inc. If the stock is listed upon an established stock exchange or exchanges, such fair market value shall be deemed to be the highest closing price of the Common Stock on such stock exchange or exchanges on the day the option is granted or if no sale of the Company's Common Stock shall have been made on any stock exchange that day, on the next preceding day on which there was a sale of such stock. If there is no established market for the stock, the fair market value shall be determined by the most recent prior private sale price of the Common Stock. Subject to the foregoing, the Board of Directors in fixing the option price shall have full authority and discretion so long as they shall act in good faith. (v) Limitation on Time of Grant. No Incentive Stock Option shall be granted on or after the tenth anniversary of the effective date of the Plan. (vi) Conversion of Incentive Stock Options. The Board of Directors may at any time without the consent of the optionee convert an Incentive Stock Option to a Non-Statutory Stock Option. (c) Non-Statutory Stock Options. Non-Statutory Stock Options shall be subject to the following terms and conditions in addition to those set forth in paragraph 6(a) above: (i) Option Price. The option price for Non-Statutory Stock Options shall be determined by the Board of Directors at the time of grant and may be any amount determined by the Board of Directors. 4 (ii) Duration of Options. Non-Statutory Stock Options granted under the Plan shall continue in effect for the period fixed by the Board of Directors. 7. Stock Bonuses. The Board of Directors may award shares under the Plan as stock bonuses. Shares awarded as a bonus shall be subject to the terms, conditions and restrictions determined by the Board of Directors (which may be based on continuous service with the Company or the achievement of performance goals related to profits, profit growth, profit-related return ratios, cash flow or total stockholder return, where such goals may be stated in absolute terms or relative to comparison companies), as the Committee shall determine in its sole discretion, which terms, conditions and restrictions shall be set forth in the instrument evidencing the award. The restrictions may include restrictions concerning transferability and forfeiture of the shares awarded, together with such other restrictions as may be determined by the Board of Directors. If shares are subject to forfeiture, all dividends or other distributions paid by the Company with respect to the shares shall be retained by the Company until the shares are no longer subject to forfeiture, at which time all accumulated amounts shall be paid to the recipient. The Board of Directors may require the recipient to sign an agreement as a condition of the award, but may not require the recipient to pay any monetary consideration other than amounts necessary to satisfy tax withholding requirements. The agreement may contain any terms, conditions, restrictions, representations and warranties required by the Board of Directors. The certificates representing the shares awarded shall bear any legends required by the Board of Directors. The Company may require any recipient of a stock bonus to pay to the Company in cash upon demand amounts necessary to satisfy any applicable federal, state or local tax withholding requirements. If the recipient fails to pay the amount demanded, the Company may withhold that amount from other amounts payable by the Company to the recipient, including salary or fees for services, subject to applicable law. With the consent of the Board of Directors, a recipient may deliver Common Stock to the Company to satisfy this withholding obligation. Upon the issuance of a stock bonus, the number of shares reserved for issuance under the Plan shall be reduced by the number of shares issued. 8. Restricted Stock. The Board of Directors may issue shares under the Plan for such consideration (including promissory notes and services) as determined by the Board of Directors. Shares issued under the Plan shall be subject to the terms, conditions and restrictions determined by the Board of Directors. The restrictions may include restrictions concerning transferability, repurchase by the Company and forfeiture of the shares issued, together with such other restrictions as may be determined by the Board of Directors. If shares are subject to forfeiture or repurchase by the Company, all dividends or other distributions paid by the Company with respect to the shares shall be retained by the Company until the shares are no longer subject to forfeiture or repurchase, at which time all accumulated amounts shall be paid to the recipient. All Common Stock issued pursuant to this paragraph 8 shall be subject to a purchase agreement, which shall be executed by the Company and the prospective recipient of the shares prior to the delivery of certificates representing such shares to the recipient. The purchase agreement may contain any terms, conditions, restrictions, representations and warranties required by the Board of Directors. The certificates representing the shares shall bear any legends required by the Board of Directors. The Company may require any purchaser of restricted stock to pay to the Company in cash upon demand amounts necessary to satisfy any applicable federal, state or local tax withholding requirements. If the purchaser fails to pay the amount demanded, the Company may withhold that amount from other amounts payable by the Company to the purchaser, including salary, subject to the applicable law. With the consent of the Board of Directors, a purchaser may deliver Common Stock to the Company to satisfy this withholding obligation. Upon the issuance of restricted stock, the number of shares reserved for issuance under the Plan shall be reduced by the number of shares issued. 9. Stock Appreciation Rights. (a) Grant. Stock appreciation rights may be granted under the Plan by the Board of Directors, subject to such rules, terms and conditions as the Board of Directors prescribes. (b) Exercise. (i) Each stock appreciation right shall entitle the holder, upon exercise, to receive from the Company in exchange therefor an amount equal in value to the excess of the fair market value on the date of exercise of one share of Common Stock of the Company over its fair market value on the date of grant (or, in the case of a stock appreciation right granted in connection with an option, the excess of the fair market value of one share of Common Stock of the Company over the option price per share under the option to which the stock appreciation right relates), multiplied by the number of 5 shares covered by the stock appreciation right or the option, or portion thereof, that is surrendered. No stock appreciation right shall be exercisable at a time that the amount determined under this subparagraph is negative. Payment by the Company upon exercise of a stock appreciation right may be made in Common Stock valued at fair market value, in cash, or partly in Common Stock and partly in cash, all as determined by the Board of Directors. (ii) A stock appreciation right shall be exercisable only at the time or times established by the Board of Directors. If a stock appreciation right is granted in connection with an option, the following rules shall apply: (1) the stock appreciation right shall be exercisable only to the extent and on the same conditions that the related option could be exercised; (2) upon exercise of the stock appreciation right, the option or portion thereof to which the stock appreciation right relates terminates; and (3) upon exercise of the option, the related stock appreciation right or portion thereof terminates. (iii) The Board of Directors may withdraw any stock appreciation right granted under the Plan at any time and may impose any conditions upon the exercise of a stock appreciation right or adopt rules and regulations from time to time affecting the rights of holders of stock appreciation rights. Such rules and regulations may govern the right to exercise stock appreciation rights granted prior to adoption or amendment of such rules and regulations as well as stock appreciation rights granted thereafter. (iv) For purposes of this paragraph 9, the fair market value of the Common Stock shall be determined as of the date the stock appreciation right is exercised, under the methods set forth in paragraph 6(b)(iv). (v) No fractional shares shall be issued upon exercise of a stock appreciation right. In lieu thereof, cash may be paid in an amount equal to the value of the fraction or, if the Board of Directors shall determine, the number of shares may be rounded downward to the next whole share. (vi) Each stock appreciation right granted in connection with an Incentive Stock Option, and unless otherwise determined by the Board of Directors with respect to a stock appreciation right granted to a person who is neither an Officer nor a Director of the Company, each other stock appreciation right granted under the Plan by its terms shall be nonassignable and nontransferable by the holder, either voluntarily or by operation of law, except by will or by the laws of descent and distribution of the state or country of the holder's domicile at the time of death, and each stock appreciation right by its term shall be exercisable during the holder's lifetime only by the holder; provided, however, that a stock appreciation right not granted in connection with an Incentive Stock Option shall also be transferable pursuant to a qualified domestic relations order as defined under the Code or ERISA. (vii) Each participant who has exercised a stock appreciation right shall, upon notification of the amount due, pay to the Company in cash amounts necessary to satisfy any applicable federal, state or local tax withholding requirements. If the participant fails to pay the amount demanded, the Company may withhold that amount from other amounts payable by the Company to the participant including salary, subject to applicable law. With the consent of the Board of Directors a participant may satisfy this obligation, in whole or in part, by having the Company withhold from any shares to be issued upon the exercise that number of shares that would satisfy the withholding amount due or by delivering Common Stock to the satisfy the withholding amount. (viii) Upon the exercise of a stock appreciation right for shares, the number of shares reserved for issuance under the Plan shall be reduced by the number of shares issued. Cash payments of stock appreciation rights shall not reduce the number of shares of Common Stock reserved for issuance under the Plan. 10. Cash Bonus Rights. (a) Grant. The Board of Directors may grant cash bonus rights under the Plan in connection with: (i) options granted or previously granted; (ii) stock appreciation rights granted or previously granted; (iii) stock bonuses awarded or previously awarded; and (iv) shares sold or previously sold under the Plan. Cash bonus rights will be subject to rules, terms and conditions as the Board of Directors may prescribe. Unless otherwise determined by the Board of Directors with respect to a cash bonus right granted to a person who is neither an Officer nor a Director of the Company, each cash bonus right granted under the Plan by its terms shall be nonassignable and nontransferable by the holder, either voluntarily or by 6 operation of law, except by will or by the laws of descent and distribution of the state or country of the holder's domicile at the time of death or pursuant to a qualified domestic relations order as defined under the Code or ERISA. The payment of a cash bonus shall not reduce the number of shares of Common Stock reserved for issuance under the Plan. (b) Cash Bonus Rights in Connection With Option. A cash bonus right granted in connection with an option will entitle an optionee to a cash bonus when the related option is exercised (or terminates in connection with the exercise of a stock appreciation right related to the option) in whole or in part. If an optionee purchases shares upon exercise of an option and does not exercise a related stock appreciation right, the amount of the bonus shall be determined by multiplying the excess of the total fair market value of the shares to be acquired upon the exercise over the total option price for the shares by the applicable bonus percentage. If the optionee exercises a related stock appreciation right in connection with the termination of an option, the amount of the bonus shall be determined by multiplying the total fair market value of the shares and cash received pursuant to the exercise of the stock appreciation right by the applicable bonus percentage. The bonus percentage applicable to a bonus right shall be determined from time to time by the Board of Directors but shall in no event exceed 75 percent. (c) Cash Bonus Rights in Connection With Stock Bonus. A cash bonus right granted in connection with a stock bonus will entitle the recipient to a cash bonus payable when the stock bonus is awarded or when restrictions, if any, to which the stock is subject lapse. If bonus stock awarded is subject to restrictions and is repurchased by the Company or forfeited by the holder, the cash bonus right granted in connection with the stock bonus shall terminate and may not be exercised. The amount and timing of payment of a cash bonus shall be determined by the Board of Directors. (d) Cash Bonus Rights in Connection With Stock Purchase. A cash bonus right granted in connection with the purchase of stock pursuant to paragraph 8 will entitle the recipient to a cash bonus when the shares are purchased or when restrictions, if any, to which the stock is subject lapse. Any cash bonus right granted in connection with shares purchased pursuant to paragraph 8 shall terminate and may not be exercised in the event the shares are repurchased by the Company or forfeited by the holder pursuant to applicable restrictions. The amount of any cash bonus to be awarded and timing of payment of a cash bonus shall be determined by the Board of Directors. (e) Taxes. The Company shall withhold from any cash bonus paid pursuant to this paragraph 10 the amount necessary to satisfy any applicable federal, state and local withholding requirements. 11. Performance Units. The Board of Directors may grant performance units consisting of monetary units which may be earned in whole or in part if the Company achieves certain goals established by the Board of Directors over a designated period of time, but not in any event more than 10 years. The goals established by the Board of Directors may include earnings per share, return on stockholders' equity, return on invested capital, and such other goals as may be established by the Boards of Directors. In the event that the minimum performance goal established by the Board of Directors is not achieved at the conclusion of a period, no payment shall be made to the participants. In the event the maximum corporate goal is achieved, 100 percent of the monetary value of the performance units shall be paid to or vested in the participants. Partial achievement of the maximum goal may result in a payment or vesting corresponding to the degree of achievement as determined by the Board of Directors. Payment of an award earned may be in cash or in Common Stock or in a combination of both, and may be made when earned, or vested and deferred, as the Board of Directors determines. Deferred awards shall earn interest on the terms and at a rate determined by the Board of Directors. Unless otherwise determined by the Board of Directors with respect to a performance unit granted to a person who is neither an Officer nor a Director of the Company, each performance unit granted under the Plan by its terms shall be nonassignable and nontransferable by the holder, either voluntarily or by operation of law, except by will or by the laws of descent and distribution of the state or country of the holder's domicile at the time of death or pursuant to a qualified domestic relations order as defined under the Code or ERISA. Each participant who has been awarded a performance unit shall, upon notification of the amount due, pay to the Company in cash amounts necessary to satisfy any applicable federal, state and local tax withholding requirements. If the participant fails to pay the amount demanded, the Company may withhold that amount from other amounts payable by the Company to the participant, including salary or fees for services, subject to applicable law. With the consent of the Board of Directors a participant may satisfy this obligation, in whole or in part, by having the Company withhold from any shares to be issued that number of shares that would satisfy the withholding amount due or by delivering Common Stock to the Company to satisfy the withholding amount. The payment of a performance unit in cash shall not reduce the number of shares of Common Stock 7 reserved for issuance under the Plan. The number of shares reserved for issuance under the Plan shall be reduced by the number of shares issued upon payment of an award. 12. Foreign Qualified Grants. Awards under the Plan may be granted to such Officers and employees of the Company and its subsidiaries and such other persons described in paragraph 1 residing in foreign jurisdictions as the Board of Directors may determine from time to time. The Board of Directors may adopt such supplements to the Plan as may be necessary to comply with the applicable laws of such foreign jurisdictions and to afford participants favorable treatment under such laws; provided, however, that no award shall be granted under any such supplement with terms which are more beneficial to the participants than the terms permitted by the Plan. 13. Formula Awards to Committee Members. Each Director appointed to the Committee shall be granted Non-Statutory Stock Options for 30,000 shares of Common Stock on the day such Committee member is so appointed and thereafter further grants of Non-Statutory Stock Options for 30,000 shares of Common Stock on the third anniversary of the grant of such Committee member's most prior grant under this paragraph 13; provided, however, that the aggregate grant to newly appointed Committee members shall be reduced on an option for option basis by the amount of any option grants accepted by such appointee from the Company within the prior 24-month period (the "Formula Options"). The Formula Options granted to such Committee member shall have an exercise price per share equal to the fair market value of Common Stock on the date of grant. Each Formula Option granted under this paragraph 13 shall become exercisable in three equal installments on each of the first three anniversaries of the date of grant. Each portion of each Formula Option granted under this paragraph 13 shall be exercisable for 10 years after the date of grant. Upon termination of a Director's membership on the Board other than due to such Director's death or "total disability" (as defined in paragraph 6(a)(4)(B)), any Formula Options which are then exercisable may be exercised by such Director at any time prior to the expiration of such option's term or within three months following such cessation of membership, whichever period is shorter. The exercise price for each Formula Option granted pursuant to this paragraph 13 is payable in the manner prescribed in paragraph 6(a)(v). The terms and provisions of this Plan shall also apply to the grant and exercise of Formula Options, to the extent such other provisions do not contradict the express provisions of this paragraph 13. 14. Changes in Capital Structure. If the outstanding Common Stock of the Company is hereafter increased or decreased or changed into or exchanged for a different number or kind of shares or other securities of the Company or of another corporation by reason of any reorganization, merger, consolidation, plan of exchange, recapitalization, reclassification, stock split-up, combination of shares or dividend payable in shares, appropriate adjustment shall be made by the Board of Directors in the number and kind of shares available for awards under the Plan. In addition, except with respect to transactions referred to in paragraph 15, the Board of Directors shall make appropriate adjustment in the number and kind of shares as to which outstanding options and stock appreciation rights, or portions thereof then unexercised, shall be exercisable, so that the optionee's proportionate interest before and after the occurrence of the event is maintained. Notwithstanding the foregoing, the Board of Directors shall have no obligation to effect any adjustment that would or might result in the issuance of fractional shares, and any fractional shares resulting from any adjustment may be disregarded or provided for in any manner determined by the Board of Directors. Any such adjustments made by the Board of Directors shall be conclusive. If the stockholders of the Company receive capital stock from another corporation ("Exchange Stock") in exchange for their shares of Common Stock in any transaction involving a merger, consolidation or plan of exchange, all options granted hereunder shall be converted into options to purchase shares of Exchange Stock (unless the Company and the corporation issuing the Exchange Stock, in their sole discretion, determine that any or all such options granted hereunder are to be treated as set forth in the following sentence) in the same proportion as used for determining the number of shares of Exchange Stock the holders of the Common Stock receive in such merger. In the event of dissolution of the Company or a merger, consolidation or plan of exchange affecting the Company to which paragraph 15 does not apply, in lieu of providing for options and stock appreciation rights as provided above in this paragraph 14, the Board of Directors may, in its sole discretion, provide 30-day period prior to such event during which optionees shall have the right to exercise options and stock appreciation rights in whole or in part without any limitation on exercisability and upon the expiration of which 30-day period all unexercised options and stock appreciation rights shall immediately terminate. 15. Acceleration in Certain Events. Notwithstanding any other provisions of the Plan, all options and stock appreciation rights outstanding under the Plan shall immediately become exercisable in full for the remainder of their terms at any time when any one of the following events has taken place: 8 (a) The stockholders of the Company approve one of the following ("Approved Transactions"): (i) Any consolidation, merger or plan of exchange, involving the Company ("Merger") pursuant to which Common Stock would be converted into cash; or (ii) Any sale, lease, exchange or other transfer (in one transaction or a series of related transactions) of all or substantially all of the assets of the Company or the adoption of any plan or proposal for the liquidation or dissolution of the Company; or (b) A tender or exchange offer, other than one made by the Company, is made for Common Stock (or securities convertible into Common stock) and such offer results in a portion of those securities being purchased and the offeror after the consummation of the offer is the beneficial owner (as determined pursuant to Section 13(d) of the Exchange Act), directly or indirectly, of at least 20 percent of the outstanding Common Stock (an "Offer"); or (c) The Company receives a report on Schedule 13D under the Exchange Act reporting the beneficial ownership by any person of 20 percent or more of the Company's outstanding Common Stock, except that if such receipt shall occur during a tender offer or exchange offer by any person other than the Company or a wholly owned subsidiary of the Company, acceleration of exercisability shall not take place until the conclusion of such offer; or (d) During any period of 12 months or less, individuals who at the beginning of such period constituted a majority of the Board of Directors cease for any reason to constitute a majority thereof unless the nomination or election of such new Directors was approved by a vote of at least two-thirds of the Directors then still in office who were Directors at the beginning of such period. All options and stock appreciation rights that are accelerated pursuant to this paragraph 15 shall terminate upon the dissolution of the Company or upon the consummation of any Merger pursuant to which Common Stock would be converted to cash. The terms used in this paragraph 15 and not defined elsewhere in the Plan shall have the same meanings as such terms have in the Exchange Act and the rules and regulations adopted thereunder. 16. Corporate Mergers, Acquisitions, etc. The Board of Directors may also grant options, stock appreciation rights, performance units, stock bonuses and cash bonuses, and issue restricted stock under the Plan having terms, conditions and provisions that vary from those specified in this Plan provided that any such awards are granted in substitution for, or in connection with the assumption of, existing options, stock appreciation rights, stock bonuses, cash bonuses, restricted stock and performance units granted, awarded or issued by another corporation and assumed or otherwise agreed to be provided for by the Company pursuant to or by reason of a transaction involving a corporate merger, consolidation, acquisition of property or stock, separation, reorganization or liquidation to which the Company or a subsidiary is a party. 17. Amendment of Plan. The Board of Directors may at any time, and from time to time, modify or amend the Plan in such respects as it shall deem advisable because of changes in the law while the Plan is in effect or for any other reason. Except as provided in paragraphs 6(a) (iv), 9, 14 and 15, however, no change in an award already granted shall be made without the written consent of the holder of such award. Notwithstanding any of the foregoing, stockholder approval (sufficient under applicable state law) is required for any Plan amendment which: (a) materially increases the total number of shares subject to the Plan (except as provided in paragraph 14); (b) materially modifies the class of eligible employees under the Plan; or (c) effects a change relating to Incentive Stock Options which is inconsistent with the Code, ERISA, or rules and regulations adopted thereunder. 18. Approvals. The obligations of the Company under the Plan are subject to the approval of state and federal authorities or agencies with jurisdiction in the matter. The Company will use its best efforts to take steps required by state or federal law or applicable regulations, including rules and regulations of the Securities and Exchange Commission and any stock exchange on which the Company's shares may then be listed, in connection with the grants under the Plan. The foregoing notwithstanding, the Company shall not be obligated to issue or deliver Common Stock under the Plan if such issuance or delivery would violate applicable state or federal securities laws. 9 19. Employment and Service Rights. Nothing in the Plan, or any award pursuant to the Plan, shall: (i) confer upon any employee any right to be continued in the employment of the Company or any subsidiary or interfere in any way with the right of the Company or any subsidiary by whom such employee is employed to terminate such employee's employment at any time, for any reason, with or without cause, or to decrease such employee's compensation or benefits; or (ii) confer upon any person engaged by the Company any right to be retained or employed by the Company or to the continuation, extension, renewal or modification of any compensation, contract or arrangement with or by the Company. 20. Rights as a Stockholder. The recipient of any award under the Plan shall have no rights as a stockholder with respect to any Common Stock until the date of issue to the recipient of a stock certificate for such shares. Except as otherwise expressly provided in the Plan, no adjustment shall be made for dividend or other rights for which the record date occurs prior to the date such stock certificate is issued. 10 PROXY FOR THE SPECIALANNUAL MEETING OF STOCKHOLDERS TO BE HELD MARCH 8, 2001JUNE 28, 2007 THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS The undersigned hereby appoints Steven T. FrankelWalter W. Witoshkin and William H. Fleming, and each of them, as Proxies, with full power of substitution, and hereby authorizes them to represent and to vote, as designed below, all the shares of Common Stock of A-Fem MedicalQuantRx Biomedical Corporation (the "Company") held of record by the undersigned on January 30, 2001,December 31, 2006, at the SpecialAnnual Meeting of Stockholders to be held on March 8, 2001June 28, 2007 or at any adjournment thereof. 1. Election and Ratification of Directors. ElectionElections of the following threetwo nominees to serve as Class 1 directors for a one-yeartwo-year term or until their successors are duly elected and qualified. Merry Disney James E. Reinmuth RoseAnna SevcikShalom Hirschman William Fleming |_| FOR all nominees |_| WITHHOLD AUTHORITY to vote for all nominees |_| WITHHOLD AUTHORITY for the following only: (write the name(s) of the nominee(s) in this space) ElectionRatification of the following four nomineesappointment to serve as a Class 2 directorsdirector for athe remainder of the two-year term or until their successors arehis successor is duly elected and qualified. William H. Fleming Steven T. Frankel Carol A. Scott James R. WilsonArthur Hull Hayes, Jr. |_| FOR all nomineesappointee |_| WITHHOLD AUTHORITY to vote for all nominees |_| WITHHOLD AUTHORITY forThis proxy, when properly executed, will be voted in the following only: (writemanner directed herein by the name(s) ofundersigned. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED "FOR ALL NOMINEES" AND "FOR APPOINTEE." 2. RATIFICATION OF 2007 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN. Ratify the nominee(s) in this space) - -------------------------------------------------------------------------------- 2. Amendment of the Company's Articles of Incorporation to Increase the Authorized Number of Shares of the Company's Common Stock and Preferred Stock. Amend the Company's Articles of Incorporation to increase the authorized number of shares of the Company's Common Stock and Preferred Stock. |_| FOR |_| AGAINST |_| ABSTAIN - -------------------------------------------------------------------------------- -1- 3. Amendment of the A-Fem Medical Corporation 19942007 Incentive and Non-Qualified Stock Option Plan. Amend the A-Fem Medical Corporation 1994 Incentive and Non-Qualified Stock Option Plan (the "1994 Plan") to increase the number of shares of the Company's Common Stock reserved for issuance under the 1994 Plan. |_| FOR |_| AGAINST |_| ABSTAIN - -------------------------------------------------------------------------------- 4. Ratification of Independent Auditors for 2001. Ratify the selection of Arthur Andersen LLP as the Company's independent auditors for the fiscal year ending December 31, 2001. |_| FOR |_| AGAINST |_| ABSTAIN This proxy, when properly executed, will be voted in the manner directed herein by the undersigned. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED "FOR THE NOMINEES" IN ITEM 1RATIFICATION OF 2007 INCENTIVE AND "FOR" ITEMS 2, 3NON-QUALIFIED STOCK OPTION PLAN." 15 3. RATIFICATION OF INDEPENDENT AUDITORS FOR FY2007. Ratify the selection of Williams & Webster, P.S. as the Company's independent auditors for the fiscal year ending December 31, 2007. |_| FOR |_| AGAINST |_| ABSTAIN This proxy, when properly executed, will be voted in the manner directed herein by the undersigned. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED "FOR THE RATIFICATION OF WILLIAMS AND 4.WEBSTER, P.S." Please sign below exactly as your name appears on your stock certificate. When shares are held jointly, each person should sign. When signing as attorney, executor, administrator, trustee or guardian, please give full title as such. An authorized person should sign on behalf of corporations, partnerships, limited liabilitiesliability companies and associations and give his or her title. Dated: , 2001 ----------------------------------- ----------------------------------------------- -----------------------------------------------2007 ------------------------------------ ------------------------------------------------ Signature ----------------------------------------------------------------------------------------------- Signature if held jointly YOUR VOTE IS IMPORTANT. PROMPT RETURN OF THIS PROXY CARD WILL HELP SAVE THE EXPENSE OF ADDITIONAL SOLICITATION EFFORTS. 16 EXHIBIT A QUANTRX BIOMEDICAL CORPORATION (the "Company") AUDIT COMMITTEE CHARTER Adopted by the Board of Directors of QuantRx Biomedical Corporation on April 26, 2007 Purpose The purpose of the Audit Committee (the "Committee") shall be as follows: 1. To oversee the accounting and financial reporting processes of the Company and audits of the financial statements of the Company. 2. To provide assistance to the Board of Directors with respect to its oversight of the following: (a) The integrity of the Company's financial statements. (b) The Company's compliance with legal and regulatory requirements. (c) The independent auditor's qualifications and independence. (d) The performance of the Company's internal audit function, if any, and independent auditor. 3. To prepare the report that SEC rules require be included in the Company's annual proxy statement. Composition The Committee shall consist of two or more members of the Board of Directors, each of whom is determined by the Board of Directors to be "independent" under Rule 10A-3(b)(1) under the rules of a national securities exchange or national securities association and the Securities Exchange Act of 1934 adopted pursuant to the Sarbanes-Oxley Act. One director who is not independent as defined in the rules of a national securities exchange or national securities association but who satisfies the requirements of Rule 10A-3(b)(1) under the Securities Exchange Act of 1934 may serve as a member of the Committee, in the following circumstances: o the director, other than in his or her capacity as a member of the Committee, the Board of Directors, or another Board committee, does not accept directly or indirectly any consulting, advisory, or other compensatory fee from the Company or any of its subsidiaries other than the receipt of fixed amounts of compensation under a retirement plan (including deferred compensation) for prior service with the Company so long as such compensation is not contingent in any way on continued service; 1 o the director is not an affiliated person of the Company or any of its subsidiaries; o the director is not a current officer or employee of the Company or an immediate family member of a current officer or employee; o the Board determines, under exceptional and limited circumstances, that membership by the individual on the Committee is required by the best interests of the Company and its shareholders; o the Board of Directors discloses, in the Company's next annual meeting proxy statement (or its next annual report on Form 10-K or its equivalent if the Company does not file an annual proxy statement) subsequent to such determination, the nature of the relationship and the reason for that determination; o no such person may serve as the Chairman of the Committee; and o no such person may serve on the Committee for more than two years. No member of the Committee shall receive directly or indirectly any consulting, advisory, or other compensatory fees from the Company other than (1) director's fees for service as a director of the Company, including reasonable compensation for serving on Board committees and regular benefits that other directors receive; and (2) a pension or similar compensation for past performance, provided that such compensation is not conditioned on continued or future service to the Company. In addition, no member of the Committee may be an affiliate of the Company or any subsidiary of the Company whether by being an officer or owning more than 10 percent of the Company's voting securities. Qualifications All members of the Committee shall be able to read and understand fundamental financial statements (including a company's balance sheet, income statement, and cash flow statement) and at least one member must either have past employment experience in finance or accounting, requisite professional certification in accounting, or any other comparable experience or background, which results in the individual's financial sophistication, including being or having been a chief executive officer, chief financial officer, or other senior officer with financial oversight responsibilities or be an "audit committee financial expert" as defined by the SEC. Committee members may enhance their familiarity with finance and accounting by participating in educational programs conducted by the Company or by an outside organization. Appointment and Removal The members of the Committee shall be appointed by the Board of Directors. A member shall serve until such member's successor is duly elected and qualified or until such member's earlier resignation or removal. The members of the Committee may be removed, with or without cause, by a majority vote of the Board of Directors. 2 Chairman Unless a Chairman is elected by the full Board of Directors, the members of the Committee shall designate a Chairman by the majority vote of the full Committee membership. The Chairman will chair all regular sessions of the Committee and set the agendas for Committee meetings. Delegation to Subcommittees In fulfilling its responsibilities, the Committee shall be entitled to delegate any or all of its responsibilities to a subcommittee of the Committee. Meetings The Committee shall meet as frequently as circumstances dictate, but at least on a quarterly basis. The Chairman of the Committee or a majority of the members of the Committee may call meetings of the Committee. Any one or more of the members of the Committee may participate in a meeting of the Committee by means of conference call or similar communication device by means of which all persons participating in the meeting can hear each other. All non-management directors who are not members of the Committee may attend meetings of the Committee, but may not vote. In addition, the Committee may invite to its meetings any director, member of management of the Company, and such other persons as it deems appropriate in order to carry out its responsibilities. The Committee may also exclude from its meetings any persons it deems appropriate. As part of its goal to foster open communication, the Committee shall periodically meet separately with each of management, the director of the internal auditing department, if any, and the independent auditor to discuss any matters that the Committee or any of these groups believe would be appropriate to discuss privately. In addition, the Committee should meet with the independent auditor and management periodically to review the Company's financial statements in a manner consistent with that outlined in this Charter. Duties and Responsibilities The Committee shall carry out the duties and responsibilities set forth below. These functions should serve as a guide with the understanding that the Committee may determine to carry out additional functions and adopt additional policies and procedures as may be appropriate in light of changing business, legislative, regulatory, legal, or other conditions. The Committee shall also carry out any other duties and responsibilities delegated to it by the Board of Directors from time to time related to the purposes of the Committee outlined in this Charter. The Committee may perform any functions it deems appropriate under applicable law, rules, or regulations, the Company's by-laws, and the resolutions or other directives of the Board, including review of any certification required to be reviewed in accordance with applicable law or regulations of the SEC. In discharging its oversight role, the Committee is empowered to study or investigate any matter of interest or concern that the Committee deems appropriate. In this regard and as it otherwise deems appropriate, the Committee shall have the 3 authority, without seeking Board approval, to engage and obtain advice and assistance from outside legal and other advisors as it deems necessary to carry out its duties. The Committee also shall have the authority to receive appropriate funding, as determined by the Committee, in its capacity as a committee of the Board of Directors, from the Company for the payment of compensation to any accounting firm engaged for the purpose of preparing or issuing an audit report or performing other audit, review, or attest services for the Company; to compensate any outside legal or other advisors engaged by the Committee; and to pay the ordinary administrative expenses of the Committee that are necessary or appropriate in carrying out its duties. The Committee shall be given full access to the Company's internal audit group, if any, Board of Directors, corporate executives, and independent auditor as necessary to carry out these responsibilities. While acting within the scope of its stated purpose, the Committee shall have all the authority of the Board of Directors, except as otherwise limited by applicable law. Notwithstanding the foregoing, the Committee is not responsible for certifying the Company's financial statements or guaranteeing the independent auditor's report. The fundamental responsibility for the Company's financial statements and disclosures rests with management and the independent auditor. It also is the job of the Chief Executive Officer and senior management, rather than that of the Committee, to assess and manage the Company's exposure to risk. Documents/Reports Review 1. Discuss with management and the independent auditor, prior to public dissemination, the Company's annual audited financial statements and quarterly financial statements, including the Company's disclosures under "Management's Discussion and Analysis of Financial Condition and Results of Operations" and discuss with the independent auditors the matters required to be discussed by Statement of Auditing Standards No. 61. 2. Discuss with management and the independent auditor, prior to the Company's filing of any quarterly or annual report, (a) whether any significant deficiencies in the design or operation of internal control over financial reporting exist that could adversely affect the Company's ability to record, process, summarize, and report financial data; (b) the existence of any material weaknesses in the Company's internal control over financial reporting; and (c) the existence of any fraud, whether or not material, that involves management or other employees who have a significant role in the Company's internal control over financial reporting. 3. Discuss with management and the independent auditor the Company's earnings press releases (paying particular attention to the use of any "pro forma" or "adjusted" non-GAAP information), as well as financial information and earnings guidance provided to analysts and rating agencies. 4. Discuss with management and the independent auditor the Company's major financial risk exposures, the guidelines and policies by which risk assessment and management is undertaken, and the steps management has taken to monitor and control risk exposure. 4 Independent Auditors 5. Appoint, retain, compensate, evaluate, and terminate any accounting firm engaged by the Company for the purpose of preparing or issuing an audit report or performing other audit, review, or attest services for the Company and, in its sole authority, approve all audit engagement fees and terms as well as all non-audit engagements with the accounting firm. 6. Oversee the work of any accounting firm engaged by the Company for the purpose of preparing or issuing an audit report or performing other audit, review, or attest services for the Company, including the resolution of any disagreements between management and the independent auditor regarding financial reporting. 7. Pre-approve, or adopt procedures to pre-approve, all audit, audit-related, tax and other services permitted by law or applicable SEC regulations (including fee and cost ranges) to be performed by the independent auditor. Any pre-approved services that will involve fees or costs exceeding pre-approved levels will also require specific pre-approval by the Committee. Unless otherwise specified by the Committee in pre-approving a service, the pre-approval will be effective for the 12-month period following pre-approval. The Committee will not approve any non-audit services prohibited by applicable SEC regulations or any services in connection with a transaction initially recommended by the independent auditor, the purpose of which may be tax avoidance and the tax treatment of which may not be supported by the Internal Revenue Code and related regulations. 8. To the extent it deems it appropriate, delegate pre-approval authority to the Chairman of the Committee or any one or more other members of the Committee provided that any member of the Committee who has exercised such delegation must report any such pre-approval decisions to the Committee at its next scheduled meeting. The Committee will not delegate the pre-approval of services to be performed by the independent auditor to management. 9. Require that the independent auditor, in conjunction with the Chief Financial Officer, be responsible for seeking pre-approval for providing services to the Company and that any request for pre-approval must inform the Committee about each service to be provided and must provide detail as to the particular service to be provided. 10. Inform each accounting firm engaged for the purpose of preparing or issuing an audit report or to perform audit, review, or attest services for the Company that such firm shall report directly to the Committee. 11. Review, at least annually, the qualifications, performance, and independence of the independent auditor. In conducting its review and evaluation, the Committee should do the following: (a) At least annually obtain and review a report by the Company's independent auditor describing (i) the auditing firm's internal quality-control procedures; (ii) any material issues raised by the most recent internal quality-control review, or peer review, of the auditing firm, or by any inquiry or investigation by governmental or 5 professional authorities, within the preceding five years, respecting one or more independent audits carried out by the auditing firm, and any steps taken to deal with any such issues; and (iii) all relationships between the independent auditor and the Company. (b) Ensure the receipt from the independent auditor of a formal written statement delineating all relationships between the auditor and the Company, consistent with Independence Standards Board Standard No. 1. (c) Actively engage in a dialogue with the independent auditor with respect to any disclosed relationships or services that may impact the objectivity and independence of the auditor. (d) Take, or recommend that the full Board of Directors take, appropriate action to oversee the independence of the independent auditor. (e) Ensure the rotation of the lead audit (or coordinating) partner at least every five years, and consider whether there should be regular rotation of the audit firm itself. (f) Confirm with the independent auditor that the lead (or coordinating) audit partner, the concurring (or reviewing) partner, and each other active audit engagement team partner satisfies the rotation requirements of Rule 2-01(c)(6) of Regulation S-X. (g) Take into account the opinions of management and the Company's internal auditor (or other personnel responsible for the internal audit function), if any. Financial Reporting Process 12. In consultation with the independent auditor, management, and the internal auditor, if any, review the integrity of the Company's financial reporting processes, both internal and external. In that connection, the Committee should obtain and discuss with management and the independent auditor reports from management and the independent auditor regarding (a) all critical accounting policies and practices to be used by the Company and the related disclosure of those critical accounting policies under "Management's Discussion and Analysis of Financial Condition and Results of Operations"; (b) analyses prepared by management and/or the independent auditor setting forth significant financial reporting issues and judgments made in connection with the preparation of the financial statements, including all alternative treatments of financial information within generally accepted accounting principles that have been discussed with the Company's management, the ramifications of the use of the alternative disclosures and 6 treatments, and the treatment preferred by the independent auditor; (c) all alternative treatments of financial statements within generally accepted accounting principles that have been discussed with the Company's management, the ramifications of the use of alternative disclosures and treatments, and the treatment preferred by the independent auditor; (d) major issues regarding accounting principles and financial statement presentations, including any significant changes in the Company's selection or application of accounting principles; (e) major issues as to the adequacy of the Company's internal controls and any specific audit steps adopted in light of material control deficiencies; (f) issues with respect to the design and effectiveness of the Company's disclosure controls and procedures, management's evaluation of those controls and procedures, and any issues relating to such controls and procedures during the most recent reporting period; (g) the effect of regulatory and accounting initiatives, as well as off-balance sheet structures on the financial statements of the Company; (h) any significant matters arising from any audit, including audit problems and difficulties, whether raised by management, the internal auditor, if any, and the independent auditor, relating to the Company's financial statements; and (i) any other material written communications between the independent auditor and the Company's management. 13. Review periodically the effect of regulatory and accounting initiatives, as well as off-balance sheet structures, on the financial statements of the Company. 14. Review with the independent auditor any audit problems or difficulties encountered and management's response thereto. In this regard, the Committee will regularly review with the independent auditor (a) any audit problems or other difficulties encountered by the auditor in the course of the audit work, including any restrictions on the scope of the independent auditor's activities or on access to requested information, and any significant disagreements with management and (b) management's responses to such matters. Without excluding other possibilities, the Committee may review with the independent auditor (i) any accounting adjustments that were noted or proposed by the auditor but were "passed" (as immaterial or otherwise), (ii) any communications between the audit team and the audit firm's national office respecting auditing or accounting issues presented by the engagement, and (iii) any "management" or "internal control" letter issued, or proposed to be issued, by the independent auditor to the Company. 15. Obtain from the independent auditor assurance that the audit of the Company's financial statements was conducted in a manner consistent with Section 10A of the Securities Exchange Act of 1934, which sets forth procedures to be followed in any audit of financial statements required under the Securities Exchange Act of 1934. 16. Discuss the scope of the annual audit and review the form of the opinion the independent auditor proposes to issue. 17. Review and discuss with management and the independent auditor the responsibilities, budget, and staffing of the Company's internal audit function, if any. Legal Compliance/General 18. Review periodically, with the Company's counsel, any legal matter that could have a significant impact on the Company's financial statements. 7 19. Discuss with management and the independent auditor the Company's guidelines and policies with respect to risk assessment and risk management. The Committee will discuss the Company's major financial risk exposures and the steps management has taken to monitor and control such exposures. 20. Set clear hiring policies for employees or former employees of the independent auditor. At a minimum, these policies should provide that any accounting firm may not provide audit services to the Company if the Chief Executive Officer, Chief Financial Officer, Chief Accounting Officer, Controller, or any person serving in an equivalent position for the Company was employed by the accounting firm and participated in any capacity in the audit of the Company within one year of the initiation of the current audit. 21. Establish procedures for (i) the receipt, retention, and treatment of complaints received by the Company regarding accounting, internal accounting controls, or auditing matters; and (ii) the confidential, anonymous submission by employees of the Company of concerns regarding questionable accounting or auditing matters. 22. Unless assigned to a comparable committee or group of independent directors, review and approve all related party transactions as specified in Item 404 of Regulation S-K. 23. Review and reassess the adequacy of this Charter on an annual basis. Reports 24. Prepare all reports required to be included in the Company's proxy statement pursuant to and in accordance with applicable rules and regulations of the SEC. 25. Report regularly to the full Board of Directors. In this regard, the Committee should review with the full Board any issues that arise with respect to the quality or integrity of the Company's financial statements, the Company's compliance with legal or regulatory requirements, the performance and independence of the Company's independent auditor, and the performance of the internal audit function, if any. 26. The Committee shall provide such recommendations as the Committee may deem appropriate. The report to the Board of Directors may take the form of an oral report by the Chairman or any other member of the Committee designated by the Committee to make such report. 27. Maintain minutes or other records of meetings and activities of the Committee. Limitation of Audit Committee's Role With respect to the foregoing responsibilities and processes, the Committee recognizes that the Company's financial management, including the internal audit staff, if any, as well as the independent auditor have more time, knowledge, and detailed information regarding the Company than do Committee members. Consequently, in discharging its oversight responsibilities, the Committee will not provide or be deemed to 8 provide any expertise or special assurance as to the Company's financial statements or any professional certification as to the independent auditors' work. While the Committee has the responsibilities and powers set forth in this Charter, it is not the duty of the Committee to plan or conduct audits or to determine that the Company's financial statements and disclosures are complete and accurate and are in accordance with generally accepted accounting principles and applicable rules and regulations. These are the responsibilities of management and the independent auditor. It also is not the duty of the Committee to conduct investigations or to assure compliance with laws and regulations and the Company's internal policies and procedures. 9 EXHIBIT B QUANTRX BIOMEDICAL CORPORATION (the "Company") COMPENSATION COMMITTEE CHARTER Adopted by the Board of Directors of QuantRx Biomedical Corporation on April 26, 2007 Purpose The purpose of the Compensation Committee (the "Committee") shall be as follows: 1. To determine, or recommend to the Board of Directors for determination, the compensation for the Chief Executive Officer (the "CEO") of the Company. 2. To determine, or recommend to the Board of Directors for determination, the compensation for all officers of the Company other than the CEO. 3. To produce an annual report on executive compensation for inclusion in the Company's annual proxy statement in accordance with applicable rules and regulations of the Securities and Exchange Commission (the "SEC") and other regulatory bodies. Composition The Committee shall consist of two or more members of the Board of Directors, each of whom is determined by the Board of Directors to be "independent" under the rules of a national securities exchange or national securities association and the Sarbanes-Oxley Act. To the extent the Committee consists of at least three members, one director who is not independent may be appointed to the Committee, subject to the following: o the director is not a current officer or employee, or an immediate family member of a current officer or employee, of the Company; o the Board of Directors, under exceptional and limited circumstances, determines that such individual's membership on the Committee is required by the best interests of the Company and its stockholders; o the Company discloses in the proxy statement for the next annual meeting of stockholders subsequent to such determination (or in its Form 10-K if the Company does not file a proxy statement), the nature of the relationship and the reason for that determination; and o such person does not serve under this exception on the Committee for more than two years. 1 Appointment and Removal The members of the Committee shall be appointed by the Board of Directors. A member shall serve until such member's successor is duly elected and qualified or until such member's earlier resignation or removal. The members of the Committee may be removed, with or without cause, by a majority vote of the Board of Directors. Chairman Unless a Chairman is elected by the full Board of Directors, the members of the Committee shall designate a Chairman by majority vote of the full Committee membership. The Chairman will chair all regular sessions of the Committee and set the agendas for Committee meetings. Delegation to Subcommittees In fulfilling its responsibilities, the Committee shall be entitled to delegate any or all of its responsibilities to a subcommittee of the Committee. Meetings The Committee shall meet as frequently as circumstances dictate. The Chairman of the Committee or a majority of the members of the Committee may call meetings of the Committee. Any one or more of the members of the Committee may participate in a meeting of the Committee by means of conference call or similar communication device by means of which all persons participating in the meeting can hear each other. All non-management directors who are not members of the Committee may attend meetings of the Committee, but may not vote. In addition, the Committee may invite to its meetings any director, member of management of the Company, and such other persons as it deems appropriate in order to carry out its responsibilities. The Committee may also exclude from its meetings any persons it deems appropriate. As part of its review and establishment of the performance criteria and compensation of designated key executives, the Committee should meet separately at least on an annual basis with the CEO and any other corporate officers as it deems appropriate. However, the Committee should also meet from time to time without such officers present, and in all cases, such officers shall not be present at meetings at which their performance and compensation are being discussed and determined. Duties and Responsibilities The Committee shall carry out the duties and responsibilities set forth below. These functions should serve as a guide with the understanding that the Committee may determine to carry out additional functions and adopt additional policies and procedures as may be appropriate in light of changing business, legislative, regulatory, legal, or other conditions. The Committee shall also carry out any other responsibilities and duties delegated to it by the Board of Directors from time to time related to the purposes of the Committee outlined in this Charter. 2 In discharging its oversight role, the Committee is empowered to study or investigate any matter of interest or concern that the Committee deems appropriate and shall have the sole authority, without seeking Board approval, to retain outside counsel or other advisors for this purpose, including the authority to approve the fees payable to such counsel or advisors and any other terms of retention. Setting Compensation for Officers and Directors 1. Establish and review the overall compensation philosophy of the Company. 2. Review and approve the Company's corporate goals and objectives relevant to the compensation for the CEO and other officers, including annual performance objectives. 3. Evaluate the performance of the CEO and other officers in light of those goals and objectives and, based on such evaluation, approve, or recommend to the full Board of Directors the approval of, the annual salary, bonus, stock options, and other benefits, direct and indirect, of the CEO and other executive officers. 4. In approving or recommending the long-term incentive component of compensation for the CEO and other executive officers, the Committee should consider the Company's performance and relative stockholder return, the value of similar incentive awards to CEOs and other executive officers at comparable companies, and the awards given to the CEO and other executive officers in past years. The Committee is not precluded from approving awards (with the ratification of the Board of Directors) as may be required to comply with applicable tax laws, such as Rule 162(m). 5. In connection with executive compensation programs, the Committee should do the following: (a) Review and recommend to the full Board of Directors, or approve, new executive compensation programs; (b) Review on a periodic basis the operations of the Company's executive compensation programs to determine whether they are properly coordinated and achieving their intended purposes; (c) Establish and periodically review policies for the administration of executive compensation programs; and (d) Take steps to modify any executive compensation program that yields payments and benefits that are not reasonably related to executive and corporate performance. 6. Establish and periodically review policies in the area of senior management perquisites. 3 7. Consider policies and procedures pertaining to expense accounts of senior executives. 8. Review and recommend to the full Board of Directors compensation of directors as well as directors' and officers' indemnification and insurance matters. 9. Review and make recommendations to the full Board of Directors, or approve, any contracts or other transactions with current or former executive officers of the Company, including consulting arrangements, employment contracts, change-in-control agreements, severance agreements, or termination arrangements, and loans to employees made or guaranteed by the Company. Monitoring Incentive and Equity-Based Compensation Plans 10. Review and make recommendations to the Board of Directors with respect to, or approve, the Company's incentive-compensation plans and equity-based plans, and review the activities of the individuals responsible for administering those plans. 11. Review and make recommendations to the full Board of Directors, or approve, all equity compensation plans of the Company that are not otherwise subject to the approval of the Company's shareholders. 12. Review and make recommendations to the full Board of Directors, or approve, all awards of shares or share options pursuant to the Company's equity-based plans. 13. Monitor compliance by executives with the rules and guidelines of the Company's equity-based plans. 14. Review and monitor employee pension, profit sharing, and benefit plans. 15. Have the sole authority to select, retain, and/or replace, as needed, any compensation or other outside consultant to be used to assist in the evaluation of director, CEO, or senior executive compensation. In the event such a compensation consultant is retained, the Committee shall have the sole authority to approve such consultant's fees and other retention terms. Reports 16. Prepare an annual report on executive compensation for inclusion in the Company's proxy statement in accordance with applicable rules and regulations of the SEC, and other applicable regulatory bodies. 17. Report regularly to the Board of Directors with respect to matters that are relevant to the Committee's discharge of its responsibilities and with respect to such recommendations as the Committee may deem appropriate. The report to the Board of Directors may take the form of an 4 oral report by the Chairman or any other member of the Committee designated by the Committee to make such report. 18. Maintain minutes or other records of meetings and activities of the Committee. 5 EXHIBIT C QUANTRX BIOMEDICAL CORPORATION 2007 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN 1. Purpose. The purpose of this Plan is to advance the interests of QuantRx, Biomedical Corporation, a Nevada corporation (the "Company"), and its Related Entities by providing an additional incentive to attract and retain qualified and competent persons who provide services to the Company and its Related Entities, and upon whose efforts and judgment the success of the Company and its Related Entities is largely dependent, through the encouragement of stock ownership in the Company by such persons. This Plan will become effective on the date of its adoption by the Board, provided the Plan is approved by the stockholders of the Company (excluding holders of shares of Stock issued by the Company pursuant to the exercise of options granted under this Plan) within twelve months before or after the date. If the Plan is not so approved by the stockholders of the Company, any options granted under this Plan will be rescinded and will be void. This Plan will remain in effect until it is terminated by the Board or the Committee (as defined hereafter) under Section 9 hereof, except that no ISO (as defined herein) will be granted after the tenth anniversary of the date of this Plan's adoption by the Board. This Plan will be governed by, and construed in accordance with, the laws of the State of Nevada. 2. Definitions. As used herein, the following terms shall have the meanings indicated: (a) "Board" shall mean the Board of Directors of the Company. (b) "Cause" shall, with respect to any Optionee, have the equivalent meaning (or the same meaning as "cause" or "for cause") set forth in any employment agreement, consulting, or other agreement for the performance of services between the Optionee, and the Company or a Related Entity or, in the absence of any such agreement or any such definition in such agreement, such term shall mean (i) the failure by the Optionee to perform, in a reasonable manner, his or her duties as assigned by the Company or a Related Entity, (ii) any violation or breach by the Optionee of his or her employment agreement, consulting or other similar agreement with the Company or a Related Entity, if any, (iii) any violation or breach by the Optionee of any non-competition, non-solicitation, non-disclosure and/or other similar agreement with the Company or a Related Entity, (iv) any act by the Optionee of dishonesty or bad faith with respect to the Company (or a Related Entity), (v) use of alcohol, drugs or other similar substances in a manner that adversely affects the Optionee's work performance, or (vi) the commission by the Optionee of any act, misdemeanor, or crime reflecting unfavorably upon the Optionee or the Company or any Related Entity. The good faith determination by the Committee of whether the Optionee's Continuous Service was terminated by the Company for "Cause" shall be final and binding for all purposes hereunder. (c) "Code" shall mean the Internal Revenue Code of 1986, as amended from time to time. (d) "Committee" means a committee designated by the Board to administer the Plan; provided, however, that if the Board fails to designate a committee or if there are no longer any members on the committee so designated by the Board, then the Board shall serve as the Committee. Committee shall consist of at least two directors, and each member of the Committee shall be (i) a "non-employee director" within the meaning of Rule 16b-3 (or any successor rule) under the Exchange Act, unless administration of the Plan by "non-employee directors" is not then required in order for exemptions under Rule 16b-3 to apply to transactions under the Plan, (ii) an "outside director" within the meaning of Section 162(m) of the Code, and (iii) "Independent". (e) "Common Stock" shall mean the Company's common stock, par value $0.01 per share. (f) "Company" shall mean QuantRx Biomedical Corporation, a Nevada corporation. (g) "Consultant" shall mean any person (other than an Employee or a Director, solely with respect to rendering services in such person's capacity as a Director) who is engaged by the Company or any Related Entity to render consulting or advisory services to the Company or such Related Entity. (h) "Continuous Service" shall mean the continuous service to the Company or any Related Entity, without interruption or termination, in any capacity of Employee, Director or Consultant. Continuous Service shall not be considered interrupted in the case of (i) any approved leave of absence, (ii) transfers among the Company, any Related Entity, or any successor, in any capacity of Employee, Director or Consultant, or (iii) any change in status as long as the individual remains in the service of the Company or any Related Entity in any capacity of Employee, Director or Consultant (except as otherwise provided in the Option Agreement). An approved leave of absence shall include sick leave, military leave, or any other authorized personal leave. (i) "Director" shall mean a member of the Board or the board of directors of any Related Entity. (j) "Disability" means a permanent and total disability (within the meaning of Section 22(e) of the Code), as determined by a medical doctor satisfactory to the Committee. (k) "Effective Date" shall mean June 4, 2007. (l) "Eligible Participants" means persons who, at a particular time, are employees, officers, consultants, or directors of the Company or its subsidiaries. -2- (m) "Employee" shall mean any person, including an Officer or Director, who is an employee of the Company or any Related Entity. The payment of a Director's normal compensation and fee (as applicable to all Directors or Committee members, as the case may be) by the Company or a Related Entity shall not be sufficient to constitute "employment" by the Company. (n) "Fair Market Value" of a Share on any date of reference shall mean the "Closing Price" (as defined below) of the Common Stock on the business day immediately preceding the date of reference, unless the Committee in its sole discretion shall determine otherwise in a fair and uniform manner. For the purpose of determining Fair Market Value, the "Closing Price" of the Common Stock on any business day shall be (i) if the Common Stock is listed or admitted for trading on any United States national securities exchange, or if actual transactions are otherwise reported on a consolidated transaction reporting system, the last reported sale price of Common Stock on such exchange or reporting system, as reported in any newspaper of general circulation, (ii) if the Common Stock is quoted on the National Association of Securities Dealers Automated Quotations System ("NASDAQ"), or any similar system of automated dissemination of quotations of securities prices in common use, the last reported sale price of Common Stock on such system or, if sales prices are not reported, the mean between the closing high bid and low asked quotations for such day of Common Stock on such system, as reported in any newspaper of general circulation, or (iii) if neither clause (i) or (ii) is applicable, the mean between the high bid and low asked quotations for the Common Stock as reported by the National Quotation Bureau, Incorporated if at least two securities dealers have inserted both bid and asked quotations for Common Stock on at least five of the ten preceding days. If neither (i), (ii), or (iii) above is applicable, then Fair Market Value shall be determined by the Committee in a fair and uniform manner. (o) "Incentive Stock Option" shall mean an incentive stock option as defined in Section 422 of the Internal Revenue Code. (p) "Independent", when referring to either the Board or members of the Committee, shall have the same meaning as used in the rules of the Nasdaq Stock Market or any national securities exchange on which any securities of the Company are listed for trading, and if not listed for trading, by the rules of Nasdaq Stock Market. (q) "Non-Qualified Stock Option" shall mean an Option that is not an Incentive Stock Option. (r) "Option" (when capitalized) shall mean any option granted under this Plan. (s) "Option Agreement" shall mean the agreement between the Company and the Optionee for the grant of an option. (t) "Optionee" shall mean a person to whom a stock option is granted under this Plan or any person who succeeds to the rights of such person under this Plan by reason of the death of such person. -3- (u) "Person" shall have the meaning ascribed to such term in Section 3(a)(9) of the Securities Exchange Act and used in Sections 13(d) and 14(d) thereof, and shall include a "group" as defined in Section 13(d) thereof. (v) "Plan" shall mean this 2007 Stock Option Plan for the Company. (w) "Related Entity" shall mean any Subsidiary, and any business, corporation, partnership, limited liability company or other entity in which the Company or a Subsidiary holds a substantial ownership interest, directly or indirectly. (x) "Securities Exchange Act" shall mean the Securities Exchange Act of 1934, as amended from time to time. (y) "Share" shall mean a share of Common Stock. (z) "Subsidiary" shall mean any corporation or other entity in which the Company has a direct or indirect ownership interest of 50% or more of the total combined voting power of the then outstanding securities or interests of such corporation or other entity entitled to vote generally in the election of directors or in which the Company has the right to receive 50% or more of the distribution of profits or 50% or more of the assets on liquidation or dissolution. 3. Shares Available for Option Grants. The Committee may grant to Optionees from time to time Options to purchase an aggregate of up to 8,000,000 Common Shares from the Company's authorized and unissued Shares. If any Option granted under the Plan shall terminate, expire, or be canceled or surrendered as to any Shares, new Options may thereafter be granted covering such Shares. 4. Incentive and Non-Qualified Options. (a) An Option granted hereunder shall be either an Incentive Stock Option or a Non-Qualified Stock Option as determined by the Committee at the time of grant of the Option and the Option Agreement relating to the Option shall clearly state whether it is an Incentive Stock Option or a Non-Qualified Stock Option. All Incentive Stock Options shall be granted within 10 years from the Effective Date. Incentive Stock Options may not be granted to any person who is not an Employee of the Company or a Related Entity. (b) Options otherwise qualifying as Incentive Stock Options hereunder will not be treated as Incentive Stock Options to the extent that the aggregate fair market value (determined at the time the Option is granted) of the Shares with respect to which Options meeting the requirements of Section 422(b) of the Code are exercisable for the first time by any individual during any calendar year (under all plans of the Company and its parent corporation or subsidiary corporation, as those terms are defined in Sections 424(e) and (f) of the Code, respectively, exceeds $100,000. 5. Conditions for Grant of Options. -4- (a) Each Option shall be evidenced by an Option Agreement that may contain any term deemed necessary or desirable by the Committee, provided such terms are not inconsistent with this Plan or any applicable law. Optionees shall be those persons who are selected by the Committee from the class of all Employees, Directors and Consultants of the Company or any Related Entity. (b) In granting Options, the Committee shall take into consideration the contribution the person has made to the success of the Company or any Related Entities and such other factors as the Committee shall determine. The Committee shall also have the authority to consult with and receive recommendations from officers and other personnel of the Company and its Related Entities with regard to these matters. The Committee may from time to time in granting Options under the Plan prescribe such other terms and conditions concerning such Options as it deems appropriate, including, without limitation, (i) prescribing the date or dates on which the Option becomes exercisable, (ii) providing that the Option rights accrue or become exercisable in installments over a period of years, or upon the attainment of stated goals or both, or (iii) relating an Option to the Continuous Service or continued employment of the Optionee for a specified period of time, provided that such terms and conditions are not more favorable to an Optionee than those expressly permitted herein. (c) The Options granted to Optionees under this Plan shall be in addition to regular salaries, pension, life insurance or other benefits related to their Continuous Service with the Company or its Related Entities. Neither the Plan nor any Option granted under the Plan shall confer upon any person any right to continuance of any Continuous Service by the Company or its Related Entities. (d) The Committee shall have the discretion to grant Options that are exercisable for unvested Shares. Should the Optionee's Continuous Service cease while holding such unvested Shares, the Company shall have the right to repurchase, at the exercise price paid per share, any or all of those unvested Shares. The terms upon which such repurchase right shall be exercisable (including the period and procedure for exercise and the appropriate vesting schedule for the purchased shares) shall be established by the Committee and set forth in the Option Agreement for the relevant Option. (e) Notwithstanding any other provision of this Plan, an Incentive Stock Option shall not be granted to any person owning directly or indirectly (through attribution under Section 424(d) of the Code) at the date of grant, stock possessing more than 10% of the total combined voting power of all classes of stock of the Company (or of any parent corporation or subsidiary corporation of the Company (as those terms are defined in Sections 424(e) and 424(f) of the Code, respectively) at the date of grant) unless the exercise price of such Option is at least 110% of the Fair Market Value of the Shares subject to such Option on the date the Option is granted, and such Option by its terms is not exercisable after the expiration of five years from the date such Option is granted. (f) Notwithstanding any other provision of this Plan, and in addition to any other requirements of this Plan, the aggregate number of Options granted to any one Optionee may not exceed 2,000,000, subject to adjustment as provided in Section 10 hereof. -5- (g) Covenants of Optionee. At the discretion of the Committee the person to whom an Option is granted hereunder, as a condition to the granting of the Option, must execute and deliver to the Company a confidential information agreement approved by the Committee. Nothing contained in this Plan, any Option Agreement or in any other agreement executed in connection with the granting of an Option under this Plan will confer upon any Optionee any right with respect to the continuation of his or her status as an employee of, consultant or independent contractor to, or director of, the Company or its subsidiaries. (h) Vesting Periods. Except as otherwise provided herein, each option Agreement may specify the period or periods of time within which each Option or portion thereof will first become exercisable (the "Vesting Period") with respect to the total number of shares of Option Stock called for thereunder (the "Total Award Option Stock"). Such Vesting Periods will be fixed by the Committee in its discretion, and may be accelerated or shortened by the Committee in its discretion. 6. Exercise Price. The exercise price per Share of any Option shall be any price determined by the Committee but shall not be less than the par value per Share; provided, however, that in no event shall the exercise price per Share of any Incentive Stock Option be less than the Fair Market Value of the Shares underlying such Option on the date such Option is granted. 7. Exercise of Options. (a) An Option shall be deemed exercised when (i) the Company has received written notice of such exercise in accordance with the terms of the Option, (ii) full payment of the aggregate exercise price of the Shares as to which the Option is exercised has been made, and (iii) arrangements that are satisfactory to the Committee in its sole discretion have been made for the Optionee's payment to the Company of the amount that is necessary for the Company or Related Entity employing the Optionee to withhold in accordance with applicable Federal or state tax withholding requirements. (b) The consideration to be paid for the Shares to be issued upon exercise of an Option, as well as the method of payment of the exercise price and of any withholding and employment taxes applicable thereto, shall be determined by the Committee and may in the discretion of the Committee consist of: (1) cash, (2) certified or official bank check, (3) money order, (4) Shares that have been held by the Optionee for at least six (6) months (or such other Shares as the Committee determines will not cause the Company to recognize for financial accounting purposes a charge for compensation expense), (5) the withholding of Shares issuable upon exercise of the Option, (6) pursuant to a "cashless exercise" procedure, by delivery of a properly executed exercise notice together with such other documentation, and subject to such guidelines, as the Committee shall require to effect an exercise of the Option and delivery to the Company by a licensed broker acceptable to the Company of proceeds from the sale of Shares or a margin loan sufficient to pay the exercise price and any applicable income or employment taxes, or (7) in such other consideration as the Committee deems appropriate, or by a combination of the above. In the case of an Incentive Stock Option, the permissible methods of payment shall be specified at the time the Option is granted. The Committee in its sole discretion -6- may accept a personal check in full or partial payment of any Shares. If the exercise price is paid, and/or the Optionee's tax withholding obligation is satisfied, in whole or in part with Shares, or through the withholding of Shares issuable upon exercise of the Option, the value of the Shares surrendered or withheld shall be their Fair Market Value on the date the Option is exercised. (c) The Committee in its sole discretion may, on an individual basis or pursuant to a general program established in connection with this Plan, cause the Company to lend money to an Optionee, guarantee a loan to an Optionee, or otherwise assist an Optionee to obtain the cash necessary to exercise all or a portion of an Option granted hereunder or to pay any tax liability of the Optionee attributable to such exercise; provided that such loan, loan guaranty, or assistance in obtaining a loan is not in violation of the Sarbanes-Oxley Act of 2002, or any rule or regulation adopted thereunder or any other applicable law. If the exercise price is paid in whole or part with the Optionee's promissory note, such note shall (i) provide for full recourse to the maker, (ii) be collateralized by the pledge of the Shares that the Optionee purchases upon exercise of the Option, (iii) bear interest at the prime rate of the Company's principal lender, and (iv) contain such other terms as the Committee in its sole discretion shall reasonably require. (d) No Optionee shall be deemed to be a holder of any Shares subject to an Option unless and until a stock certificate or certificates for those Shares are issued to that person(s) under the terms of this Plan. No adjustment shall be made for dividends (ordinary or extraordinary, whether in cash, securities or other property) or distributions or other rights for which the record date is prior to the date the stock certificate is issued, except as expressly provided in Section 10 hereof. 8. Exercisability of Options. Any Option shall become exercisable in such amounts, at such intervals and upon such terms and/or conditions as the Committee shall provide in the Option Agreement for that Option, except as otherwise provided in this Section 8: (a) The expiration date of an Option shall be determined by the Committee at the time of grant, but in no event shall an Option be exercisable after the expiration of 10 years from the date of grant of the Option. (b) The Option Agreement relating to any Option may provide that the Option shall become immediately fully exercisable in the event of a "Change in Control" and/or shall become fully exercisable in the event that the Committee exercises its discretion to provide a cancellation notice with respect to the Option pursuant to Section 9(b) hereof. For this purpose, the term "Change in Control" shall mean the occurrence of any of the following: (i) The acquisition by any Person of Beneficial Ownership (as those terms are defined in Section 3(a)(9) of the Securities Exchange Act, of twenty percent (20%) or more of either (A) the then outstanding shares of common stock of the Company (the "Outstanding Company Common Stock") or (B) the combined voting power of the then outstanding voting securities of the Company entitled to vote generally in the election of directors (the "Outstanding Company Voting Securities); provided, however, that for purposes of -7- this Section 8(b), the following acquisitions shall not constitute a Change of Control: (w) any acquisition directly from the Company; (x) any acquisition by the Company; (y) any acquisition by any employee benefit plan (or related trust) sponsored or maintained by the Company or any Subsidiary; or (z) any acquisition by any corporation pursuant to a transaction which complies with clauses (A), (B) and (C) of subsection (iii) below; or (ii) During any period of two (2) consecutive years (not including any period prior to the Effective Date) individuals who constitute the Board on the Effective Date (the "Incumbent Board") cease for any reason to constitute at least a majority of the Board; provided, however, that any individual becoming a director subsequent to the Effective Date whose election, or nomination for election, by the Company's shareholders, was approved by a vote of at least a majority of the directors then comprising the Incumbent Board shall be considered as though such individual were a member of the Incumbent Board, but excluding, for this purpose, any such individual whose initial assumption of office occurs as a result of an actual or threatened election contest with respect to the election or removal of directors or other actual or threatened solicitation of proxies or consents by or on behalf of a Person other than the Board; or (iii) Consummation of a reorganization, merger, statutory share exchange or consolidation or similar corporate transaction involving the Company or any of its Subsidiaries, a sale or other disposition of all or substantially all of the assets of the Company, or the acquisition of assets or stock of another entity by the Company or any of its Subsidiaries (each a "Business Combination"), in each case, unless, following such Business Combination, (A) all or substantially all of the individuals and entities who were the Beneficial Owners, respectively, of the Outstanding Company Common Stock and Outstanding Company Voting Securities immediately prior to such Business Combination beneficially own, directly or indirectly, more than fifty percent (50%) of, respectively, the then outstanding shares of common stock and the combined voting power of the then outstanding voting securities entitled to vote generally in the election of directors, as the case may be, of the corporation resulting from such Business Combination (including, without limitation, a corporation which as a result of such transaction owns the Company or all or substantially all of the Company's assets either directly or through one or more subsidiaries) in substantially the same proportions as their ownership, immediately prior to such Business Combination of the Outstanding Company Common Stock and Outstanding Company Voting Securities, as the case may be, (B) no Person (excluding any employee benefit plan (or related trust) of the Company or such corporation resulting from such Business Combination) beneficially owns, directly or indirectly, twenty percent (20%) or more of, respectively, the then outstanding shares of common stock of the corporation resulting from such Business Combination or the combined voting power of the then outstanding voting securities of such corporation except to the extent that such ownership existed prior to the Business Combination and (C) at least a majority of the members of the Board of Directors of the corporation resulting from such Business Combination were members of the Incumbent Board at the time of the execution of the initial agreement, or of the action of the Board, providing for such Business Combination; or -8- (iv) Approval by the shareholders of the Company of a complete liquidation or dissolution of the Company. (c) The Committee may in its sole discretion, accelerate the date on which any Option may be exercised and may accelerate the vesting of any Shares subject to any Option or previously acquired by the exercise of any Option. 9. Termination of Option Period. (a) Unless otherwise provided in any Option Agreement, the unexercised portion of any Option shall automatically and without notice terminate and become null and void at the time of the earliest to occur of the following: (i) three months after the date on which the Optionee's Continuous Service is terminated other than by reason of (A) Cause, (B) a Disability of the Optionee as determined by a medical doctor satisfactory to the Committee, or (C) death of the Optionee; (ii) immediately upon the termination of the Optionee's Continuous Service for Cause; (iii) twelve months after the date on which the Optionee's Continuous Service is terminated by reason of a Disability as determined by a medical doctor satisfactory to the Committee; or (iv) (A) twelve months after the date of termination of the Optionee's Continuous Service by reason of the death of the Optionee, or, if later, (B) three months after the date on which the Optionee shall die if such death shall occur during the one year period specified in Subsection 9(a)(iii) hereof. (b) To the extent not previously exercised, (i) each Option shall terminate immediately in the event of (1) the liquidation or dissolution of the Company, or (2) any reorganization, merger, consolidation or other form of corporate transaction in which either the Company does not survive or the Shares are exchanged for or converted into securities issued by another entity, unless the successor or acquiring entity, or an affiliate thereof, assumes the Option or substitutes an equivalent option or right pursuant to Section 10(c) hereof, and (ii) the Committee in its sole discretion may by written notice ("cancellation notice") cancel, effective upon the consummation of any Business Combination described in Subsection 8(b)(iii) hereof, any Option that remains unexercised on the effective date of that Business Combination. The Committee shall give written notice of any proposed transaction referred to in this Section 9(b) a reasonable period of time prior to the closing date for such transaction (which notice may be given either before or after approval of such transaction), in order that Optionees may have a reasonable period of time prior to the closing date of such transaction within which to exercise any Options that then are exercisable (including any Options that may become exercisable upon the closing date of such transaction). An Optionee may condition his exercise of any Option upon the consummation of a transaction referred to in this Section 9(b). -9- 10. Adjustment of Shares. (a) If at any time while the Plan is in effect or unexercised Options are outstanding, there shall be any increase or decrease in the number of issued and outstanding Shares through the declaration of a stock dividend or through any recapitalization resulting in a stock split-up, combination or exchange of Shares, then and in that event, the Committee shall make: (i) appropriate adjustment in the maximum number of Shares available for grant under the Plan, or available for grant to any person under the Plan, so that the same percentage of the Company's issued and outstanding Shares shall continue to be subject to being so optioned; and (ii) appropriate adjustment in the number of Shares and the exercise price per Share thereof then subject to any outstanding Option, so that the same percentage of the Company's issued and outstanding Shares shall remain subject to purchase at the same aggregate exercise price. (b) Unless otherwise provided in any Option Agreement, the Committee may change the terms of Options outstanding under this Plan, with respect to the exercise price or the number of Shares subject to the Options, or both, when, in the sole discretion of the Committee, such adjustments become appropriate to preserve benefits under the Plan. (c) In the event of any proposed sale of all or substantially all of the Company's assets or any reorganization, merger, consolidation, or other form of corporate transaction in which the Company does not survive, or in which the Shares are exchanged for or converted into securities issued by another entity, the successor or acquiring entity or an affiliate thereof may, with the consent of the Committee, assume each outstanding Option or substitute an equivalent option or right. If the successor or acquiring entity or an affiliate thereof, does not cause such an assumption or substitution of any Option, then that Option shall terminate pursuant to Section 9(d) hereof upon consummation of the sale, merger, consolidation, or other corporate transaction, with or without consideration as determined by the Committee. The Committee shall give written notice of any proposed transaction referred to in this Section 10(c) a reasonable period of time prior to the closing date for such transaction (which notice may be given either before or after the approval of such transaction), in order that Participants may have a reasonable period of time prior to the closing date of such transaction within which to exercise any Options that are then exercisable (including any Options that may become exercisable upon the closing date of such transaction). A Participant may condition his exercise of any Options upon the consummation of the transaction. (d) Except as otherwise expressly provided herein, the issuance by the Company of shares of its capital stock of any class, or securities convertible into shares of capital stock of any class, either in connection with a direct sale or upon the exercise of rights or warrants to subscribe therefor, or upon conversion of shares or obligations of the Company convertible into such shares or other securities, shall not affect, and no adjustment by reason -10- thereof shall be made to, the number of or exercise price for Shares then subject to outstanding Options granted under the Plan. (e) Without limiting the generality of the foregoing, the existence of outstanding Options granted under the Plan shall not affect in any manner the right or power of the Company to make, authorize or consummate (i) any or all adjustments, recapitalizations, reorganizations or other changes in the Company's capital structure or its business; (ii) any merger or consolidation of the Company; (iii) any issue by the Company of debt securities, or preferred or preference stock that would rank above the Shares subject to outstanding Options; (iv) the dissolution or liquidation of the Company; (v) any sale, transfer or assignment of all or any part of the assets or business of the Company; or (vi) any other corporate act or proceeding, whether of a similar character or otherwise. 11. Transferability. No Incentive Stock Option, and unless the prior written consent of the Committee is obtained (which consent may be withheld for any reason) and the transaction does not violate the requirements of Rule 16b-3 promulgated under the Securities Exchange Act no Non-Qualified Stock Option, shall be subject to alienation, assignment, pledge, charge or other transfer other than by the Optionee by will or the laws of descent and distribution, and any attempt to make any such prohibited transfer shall be void. Each Option shall be exercisable during the Optionee's lifetime only by the Optionee, or in the case of a Non-Qualified Stock Option that has been assigned or transferred with the prior written consent of the Committee, only by the permitted assignee. 12. No Shares acquired by an Officer or Director pursuant to the exercise of an Option may be sold, assigned, pledged or otherwise transferred prior to the expiration of the six-month period following the date on which the Option was granted, unless the transaction does not violate the requirements of Rule 16b-3 promulgated under the Securities Exchange Act. 13. Issuance of Shares. (a) Notwithstanding any other provision of this Plan, the Company shall not be obligated to issue any Shares unless it is advised by counsel of its selection that it may do so without violation of the applicable Federal and State laws pertaining to the issuance of securities, and may require any stock so issued to bear a legend, may give its transfer agent instructions, and may take such other steps, as in its judgment are reasonably required to prevent any such violation. (b) As a condition to any sale or issuance of Shares upon exercise of any Option, the Committee may require such agreements or undertakings as the Committee may deem necessary or advisable to facilitate compliance with any applicable law or regulation including, but not limited to, the following: (i) a representation and warranty by the Optionee to the Company, at the time any Option is exercised, that he is acquiring the Shares to be issued to him for investment and not with a view to, or for sale in connection with, the distribution of any such Shares; and -11- (ii) a representation, warranty and/or agreement to be bound by any legends endorsed upon the certificate(s) for the Shares that are, in the opinion of the Committee, necessary or appropriate to facilitate compliance with the provisions of any securities laws deemed by the Committee to be applicable to the issuance and transfer of those Shares. 14. Administration of the Plan. (a) The Plan shall be administered by the Committee which shall be composed of two or more Directors. The membership of the Committee shall be constituted so as to comply at all times with the then applicable requirements for Outside Directors of Rule 16b-3 promulgated under the Securities Exchange Act and Section 162(m) of the Code. The Committee shall serve at the pleasure of the Board and shall have the powers designated herein and such other powers as the Board may from time to time confer upon it. (b) Any and all decisions or determinations of the Committee shall be made either (i) by a majority vote of the members of the Committee at a meeting or (ii) without a meeting by the unanimous written approval of the members of the Committee. (c) The Committee, from time to time, may adopt rules and regulations for carrying out the purposes of the Plan. (d) The determinations of the Committee, and its interpretation and construction of any provision of the Plan or any Option Agreement, shall be final and binding on all persons, unless determined otherwise by the Board. 15. Withholding or Deduction for Taxes. If at any time specified herein for the making of any issuance or delivery of any Option or Shares to any Optionee, any law or regulation of any governmental authority having jurisdiction in the premises shall require the Company or a Related Entity to withhold, or to make any deduction for, any taxes or to take any other action in connection with the issuance or delivery then to be made, the issuance or delivery shall be deferred until the withholding or deduction shall have been provided for by the Optionee or beneficiary, or other appropriate action shall have been taken. -12- 16. Interpretation. (a) As it is the intent of the Company that the Plan shall comply in all respects with Rule 16b-3 promulgated under the Securities Exchange Act ("Rule 16b-3"), any ambiguities or inconsistencies in construction of the Plan shall be interpreted to give effect to such intention, and if any provision of the Plan is found not to be in compliance with Rule 16b-3, such provision shall be deemed null and void to the extent required to permit the Plan to comply with Rule 16b-3. The Committee may from time to time adopt rules and regulations under, and amend, the Plan in furtherance of the intent of the foregoing. (b) The Plan and any Option Agreements entered into pursuant to the Plan shall be administered and interpreted so that all Incentive Stock Options granted under the Plan will qualify as Incentive Stock Options under Section 422 of the Code. If any provision of the Plan or any Option Agreement relating to an Incentive Stock Option should be held invalid for the granting of Incentive Stock Options or illegal for any reason, that determination shall not affect the remaining provisions hereof, but instead the Plan and the Option Agreement shall be construed and enforced as if such provision had never been included in the Plan or the Option Agreement. (c) This Plan shall be governed by the laws of the State of Nevada, without reference to the conflict of laws rules or principals thereof. (d) Headings contained in this Plan are for convenience only and shall in no manner be construed as part of this Plan. (e) Any reference to the masculine, feminine, or neuter gender shall be a reference to such other gender as is appropriate. 17. Amendment and Discontinuation of the Plan. The Committee may from time to time amend, suspend or terminate the Plan or any Option; provided, however, that, any amendment to the Plan shall be subject to the approval of the Company's shareholders if such shareholder approval is required by any applicable federal or state law or regulation (including, without limitation, Rule 16b-3 or to comply with Section 162(m) of the Code) or the rules of any stock exchange or automated quotation system on which the Common Stock may then be listed or granted. Except to the extent provided in Sections 9 and 10 hereof, no amendment, suspension or termination of the Plan or any Option issued hereunder shall substantially impair the rights or benefits of any Optionee pursuant to any Option previously granted without the consent of the Optionee. 18. Effective Date and Termination Date. The effective date of the Plan is the Effective Date, and the Plan shall terminate on the 10th anniversary of the Effective Date. This Plan shall be submitted to the shareholders of the Company for their approval and adoption and Options hereunder may be granted prior to such approval and adoption; provided, however, that any Incentive Stock Options granted hereunder, and if but only to the extent otherwise required by law or the rules of any stock exchange or automated quotation system on which the Common -13- Stock may be listed, any Non-Qualified Stock Options granted hereunder, prior to such approval and adoption shall be contingent upon obtaining such approval and adoption. -14-